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SMILES: OC(=O)Cc1ccc(Nc2nc(nc3CCCc23)-c2ccccc2)cc1

InChI Key: InChIKey=CGBXBUBISICLAU-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50491756   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491756
PNG
(CHEMBL2385566)
Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCc23)-c2ccccc2)cc1
Show InChI InChI=1S/C21H19N3O2/c25-19(26)13-14-9-11-16(12-10-14)22-21-17-7-4-8-18(17)23-20(24-21)15-5-2-1-3-6-15/h1-3,5-6,9-12H,4,7-8,13H2,(H,25,26)(H,22,23,24)
PDB

UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 610n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair