BDBM50493335 CHEMBL2425091

SMILES: COC1CN(CCOc2cc3c(Nc4ccc(F)c(Cl)c4)ncnc3cc2OC)C1

InChI Key: InChIKey=LOYIMXGRFMZOFX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50493335   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50493335 (CHEMBL2425091) Show SMILES COC1CN(CCOc2cc3c(Nc4ccc(F)c(Cl)c4)ncnc3cc2OC)C1 Show InChI InChI=1S/C21H22ClFN4O3/c1-28-14-10-27(11-14)5-6-30-20-8-15-18(9-19(20)29-2)24-12-25-21(15)26-13-3-4-17(23)16(22)7-13/h3-4,7-9,12,14H,5-6,10-11H2,1-2H3,(H,24,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of wild type EGFR (unknown origin) after 24 hrs by fluorescence assay				Bioorg Med Chem Lett 23: 5385-8 (2013) Article DOI: 10.1016/j.bmcl.2013.07.049 BindingDB Entry DOI: 10.7270/Q2SF3045
					More data for this Ligand-Target Pair