BindingDB PrimarySearch

BDBM50493818 OLICERIDINE::Oliceridine::TRV-130

SMILES: COc1ccsc1CNCC[C@]1(CCOC2(CCCC2)C1)c1ccccn1

InChI Key: InChIKey=DMNOVGJWPASQDL-OAQYLSRUSA-N

Data: 1 KI 4 IC50 5 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50493818
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50493818 (OLICERIDINE \| Oliceridine \| TRV-130 \| US11124523, ...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Trevena, Inc. Curated by ChEMBL					Assay Description Binding affinity to human mu opioid receptor by radio-ligand binding assay				J Med Chem 56: 8019-31 (2013) Article DOI: 10.1021/jm4010829 BindingDB Entry DOI: 10.7270/Q2FT8Q0N
Trevena, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50493818 (OLICERIDINE \| Oliceridine \| TRV-130 \| US11124523, ...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem		n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
1,3-beta-glucan synthase component GLS2 (Saccharomyces cerevisiae)	BDBM50493818 (OLICERIDINE \| Oliceridine \| TRV-130 \| US11124523, ...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Trevena, Inc. Curated by ChEMBL					Assay Description Inhibition of human ERG channel expressed in HEK293 cells by whole-cell patch clamp technique				J Med Chem 56: 8019-31 (2013) Article DOI: 10.1021/jm4010829 BindingDB Entry DOI: 10.7270/Q2FT8Q0N
Trevena, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50493818 (OLICERIDINE \| Oliceridine \| TRV-130 \| US11124523, ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a
Trevena, Inc. Curated by ChEMBL					Assay Description Agonist activity at human kappa opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation by fluores...				J Med Chem 56: 8019-31 (2013) Article DOI: 10.1021/jm4010829 BindingDB Entry DOI: 10.7270/Q2FT8Q0N
Trevena, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
L-type calcium channel alpha-1c/beta-2/alpha2delta-1 (Homo sapiens (Human))	BDBM50493818 (OLICERIDINE \| Oliceridine \| TRV-130 \| US11124523, ...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Trevena, Inc. Curated by ChEMBL					Assay Description Inhibition of human Cav 1.2 ion channel expressed in HEK293 cells by whole-cell patch clamp technique				J Med Chem 56: 8019-31 (2013) Article DOI: 10.1021/jm4010829 BindingDB Entry DOI: 10.7270/Q2FT8Q0N
Trevena, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50493818 (OLICERIDINE \| Oliceridine \| TRV-130 \| US11124523, ...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
Trevena, Inc. Curated by ChEMBL					Assay Description Agonist activity at human mu opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation by fluorescen...				J Med Chem 56: 8019-31 (2013) Article DOI: 10.1021/jm4010829 BindingDB Entry DOI: 10.7270/Q2FT8Q0N
Trevena, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Delta-type opioid receptor (Homo sapiens (Human))	BDBM50493818 (OLICERIDINE \| Oliceridine \| TRV-130 \| US11124523, ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a
Trevena, Inc. Curated by ChEMBL					Assay Description Agonist activity at human delta opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation by fluores...				J Med Chem 56: 8019-31 (2013) Article DOI: 10.1021/jm4010829 BindingDB Entry DOI: 10.7270/Q2FT8Q0N
Trevena, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50493818 (OLICERIDINE \| Oliceridine \| TRV-130 \| US11124523, ...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
Trevena, Inc. Curated by ChEMBL					Assay Description Agonist activity at human mu opioid receptor expressed in HEK293 cells assessed as beta-arrestin recruitment by chemiluminescence assay				J Med Chem 56: 8019-31 (2013) Article DOI: 10.1021/jm4010829 BindingDB Entry DOI: 10.7270/Q2FT8Q0N
Trevena, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50493818 (OLICERIDINE \| Oliceridine \| TRV-130 \| US11124523, ...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.90	n/a	n/a	n/a	n/a
Trevena, Inc. Curated by ChEMBL					Assay Description Agonist activity at human mu opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation by fluorescen...				J Med Chem 56: 8019-31 (2013) Article DOI: 10.1021/jm4010829 BindingDB Entry DOI: 10.7270/Q2FT8Q0N
Trevena, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50493818 (OLICERIDINE \| Oliceridine \| TRV-130 \| US11124523, ...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem		n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Cytochrome P450 1A2 (Rattus norvegicus)	BDBM50493818 (OLICERIDINE \| Oliceridine \| TRV-130 \| US11124523, ...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50493818 (OLICERIDINE \| Oliceridine \| TRV-130 \| US11124523, ...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50493818 (OLICERIDINE \| Oliceridine \| TRV-130 \| US11124523, ...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50493818 (OLICERIDINE \| Oliceridine \| TRV-130 \| US11124523, ...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase PC cid PC sid UniChem		n/a	n/a	4.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50493818 (OLICERIDINE \| Oliceridine \| TRV-130 \| US11124523, ...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem		n/a	n/a	1.36E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM50493818 (OLICERIDINE \| Oliceridine \| TRV-130 \| US11124523, ...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.65E+4	n/a	n/a	n/a	n/a	n/a	n/a
Trevena, Inc. Curated by ChEMBL					Assay Description Inhibition of human Nav 1.5 tonic ion channel expressed in HEK293 cells by whole-cell patch clamp technique				J Med Chem 56: 8019-31 (2013) Article DOI: 10.1021/jm4010829 BindingDB Entry DOI: 10.7270/Q2FT8Q0N
Trevena, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM50493818 (OLICERIDINE \| Oliceridine \| TRV-130 \| US11124523, ...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Trevena, Inc. Curated by ChEMBL					Assay Description Inhibition of human Nav 1.5 phasic ion channel expressed in HEK293 cells by whole-cell patch clamp technique				J Med Chem 56: 8019-31 (2013) Article DOI: 10.1021/jm4010829 BindingDB Entry DOI: 10.7270/Q2FT8Q0N
Trevena, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair