Found 5 hits for monomerid = 50494302 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Sphingosine 1-phosphate receptor 1
(Homo sapiens (Human)) | BDBM50494302
(CHEMBL3086532)Show SMILES CCn1c(OC)nnc1[C@@H](C)NS(=O)(=O)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C13H16ClFN4O3S/c1-4-19-12(16-17-13(19)22-3)8(2)18-23(20,21)9-5-6-11(15)10(14)7-9/h5-8,18H,4H2,1-3H3/t8-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 249 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description Antagonist activity at human S1P1 receptor expressed in HEK293 cells assessed as inhibition of S1P-induced decrease in cAMP formation by [35S]GTPgamm... |
Bioorg Med Chem Lett 23: 6377-89 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.058 BindingDB Entry DOI: 10.7270/Q2FR00KV |
More data for this Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 3
(Homo sapiens (Human)) | BDBM50494302
(CHEMBL3086532)Show SMILES CCn1c(OC)nnc1[C@@H](C)NS(=O)(=O)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C13H16ClFN4O3S/c1-4-19-12(16-17-13(19)22-3)8(2)18-23(20,21)9-5-6-11(15)10(14)7-9/h5-8,18H,4H2,1-3H3/t8-/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 4.88E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description Inhibition of S1P3 receptor (unknown origin) |
Bioorg Med Chem Lett 23: 6377-89 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.058 BindingDB Entry DOI: 10.7270/Q2FR00KV |
More data for this Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 4
(Homo sapiens (Human)) | BDBM50494302
(CHEMBL3086532)Show SMILES CCn1c(OC)nnc1[C@@H](C)NS(=O)(=O)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C13H16ClFN4O3S/c1-4-19-12(16-17-13(19)22-3)8(2)18-23(20,21)9-5-6-11(15)10(14)7-9/h5-8,18H,4H2,1-3H3/t8-/m1/s1 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description Inhibition of S1P4 receptor (unknown origin) |
Bioorg Med Chem Lett 23: 6377-89 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.058 BindingDB Entry DOI: 10.7270/Q2FR00KV |
More data for this Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 5
(Homo sapiens (Human)) | BDBM50494302
(CHEMBL3086532)Show SMILES CCn1c(OC)nnc1[C@@H](C)NS(=O)(=O)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C13H16ClFN4O3S/c1-4-19-12(16-17-13(19)22-3)8(2)18-23(20,21)9-5-6-11(15)10(14)7-9/h5-8,18H,4H2,1-3H3/t8-/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description Inhibition of S1P5 receptor (unknown origin) |
Bioorg Med Chem Lett 23: 6377-89 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.058 BindingDB Entry DOI: 10.7270/Q2FR00KV |
More data for this Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 1
(Homo sapiens (Human)) | BDBM50494302
(CHEMBL3086532)Show SMILES CCn1c(OC)nnc1[C@@H](C)NS(=O)(=O)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C13H16ClFN4O3S/c1-4-19-12(16-17-13(19)22-3)8(2)18-23(20,21)9-5-6-11(15)10(14)7-9/h5-8,18H,4H2,1-3H3/t8-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 383 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description Antagonist activity at human S1P1 receptor expressed in HEK293 cells assessed as inhibition of S1P-induced decrease in cAMP formation by [35S]GTPgamm... |
Bioorg Med Chem Lett 23: 6377-89 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.058 BindingDB Entry DOI: 10.7270/Q2FR00KV |
More data for this Ligand-Target Pair | |