BindingDB PrimarySearch

BDBM50497423 CHEMBL3343670

SMILES: Cl.[#7]\[#6](-[#7])=[#7]\[#6](=O)-c1ccc2-c3ccccc3C3([#6]-[#6]-[#6]-[#8]3)c2c1

InChI Key: InChIKey=VZIRLMPZNVYXDY-UHFFFAOYSA-N

Data: 7 KI 2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50497423
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50497423 (CHEMBL3343670) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc Curated by ChEMBL					Assay Description Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells				Bioorg Med Chem 22: 6026-38 (2014) Article DOI: 10.1016/j.bmc.2014.09.005 BindingDB Entry DOI: 10.7270/Q2RN3BT1
Astellas Pharma Inc Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50497423 (CHEMBL3343670) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	5.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc Curated by ChEMBL					Assay Description Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells				Bioorg Med Chem 22: 6026-38 (2014) Article DOI: 10.1016/j.bmc.2014.09.005 BindingDB Entry DOI: 10.7270/Q2RN3BT1
Astellas Pharma Inc Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50497423 (CHEMBL3343670) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	152	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc Curated by ChEMBL					Assay Description Binding affinity to serotonin 5-HT2C receptor (unknown origin)				Bioorg Med Chem 22: 6026-38 (2014) Article DOI: 10.1016/j.bmc.2014.09.005 BindingDB Entry DOI: 10.7270/Q2RN3BT1
Astellas Pharma Inc Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50497423 (CHEMBL3343670) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc Curated by ChEMBL					Assay Description Binding affinity to dopamine D2 receptor (unknown origin)				Bioorg Med Chem 22: 6026-38 (2014) Article DOI: 10.1016/j.bmc.2014.09.005 BindingDB Entry DOI: 10.7270/Q2RN3BT1
Astellas Pharma Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenergic receptor alpha-1 (Homo sapiens (Human))	BDBM50497423 (CHEMBL3343670) Show SMILES Show InChI	MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc Curated by ChEMBL					Assay Description Binding affinity to alpha1-adrenergic receptor (unknown origin)				Bioorg Med Chem 22: 6026-38 (2014) Article DOI: 10.1016/j.bmc.2014.09.005 BindingDB Entry DOI: 10.7270/Q2RN3BT1
Astellas Pharma Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50497423 (CHEMBL3343670) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc Curated by ChEMBL					Assay Description Binding affinity to muscarinic M5 receptor (unknown origin)				Bioorg Med Chem 22: 6026-38 (2014) Article DOI: 10.1016/j.bmc.2014.09.005 BindingDB Entry DOI: 10.7270/Q2RN3BT1
Astellas Pharma Inc Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50497423 (CHEMBL3343670) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc Curated by ChEMBL					Assay Description Binding affinity to serotonin 5-HT2A receptor (unknown origin)				Bioorg Med Chem 22: 6026-38 (2014) Article DOI: 10.1016/j.bmc.2014.09.005 BindingDB Entry DOI: 10.7270/Q2RN3BT1
Astellas Pharma Inc Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50497423 (CHEMBL3343670) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc Curated by ChEMBL					Assay Description Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system				Bioorg Med Chem 22: 6026-38 (2014) Article DOI: 10.1016/j.bmc.2014.09.005 BindingDB Entry DOI: 10.7270/Q2RN3BT1
Astellas Pharma Inc Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50497423 (CHEMBL3343670) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc Curated by ChEMBL					Assay Description Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolism				Bioorg Med Chem 22: 6026-38 (2014) Article DOI: 10.1016/j.bmc.2014.09.005 BindingDB Entry DOI: 10.7270/Q2RN3BT1
Astellas Pharma Inc Curated by ChEMBL					More data for this Ligand-Target Pair