BDBM50498439 CHEMBL1179566
SMILES: [H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@]2([H])C[C@@H](CC[C@]12C)OS(O)(=O)=O
InChI Key: InChIKey=MENQCIVHHONJLU-YZRLXODZSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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GluN1/GluN2B NMDA receptor (Homo sapiens (Human)) | BDBM50498439 (CHEMBL1179566) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.34E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Sciences of the Czech Republic v.v.i. Curated by ChEMBL | Assay Description Inhibition of recombinant GluN1/GluN2B receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of glutamate-evoked current by whol... | J Med Chem 58: 5950-66 (2015) Article DOI: 10.1021/acs.jmedchem.5b00570 BindingDB Entry DOI: 10.7270/Q2959MKM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1,3-beta-glucan synthase (Candida glabrata) | BDBM50498439 (CHEMBL1179566) | UniProtKB/TrEMBL GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bristol Curated by ChEMBL | Assay Description Negative allosteric modulation of GluN2A receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann... | J Med Chem 62: 3-23 (2019) Article DOI: 10.1021/acs.jmedchem.7b01640 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ionotropic glutamate receptor NMDA 1/2D (Homo sapiens (Human)) | BDBM50498439 (CHEMBL1179566) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bristol Curated by ChEMBL | Assay Description Negative allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann... | J Med Chem 62: 3-23 (2019) Article DOI: 10.1021/acs.jmedchem.7b01640 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human)) | BDBM50498439 (CHEMBL1179566) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bristol Curated by ChEMBL | Assay Description Negative allosteric modulation of GluN2B receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann... | J Med Chem 62: 3-23 (2019) Article DOI: 10.1021/acs.jmedchem.7b01640 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ionotropic glutamate receptor NMDA 1/2C (Homo sapiens (Human)) | BDBM50498439 (CHEMBL1179566) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bristol Curated by ChEMBL | Assay Description Negative allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann... | J Med Chem 62: 3-23 (2019) Article DOI: 10.1021/acs.jmedchem.7b01640 | |||||||||||
More data for this Ligand-Target Pair |