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SMILES: OC(=O)[C@H](CS)NC(=O)CCN1c2ccccc2Sc2ccccc12

InChI Key: InChIKey=ANDUCBBZAFOUAO-LBPRGKRZSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50498791   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50498791
PNG
(CHEMBL3623716)
Show SMILES OC(=O)[C@H](CS)NC(=O)CCN1c2ccccc2Sc2ccccc12 |r|
Show InChI InChI=1S/C18H18N2O3S2/c21-17(19-12(11-24)18(22)23)9-10-20-13-5-1-3-7-15(13)25-16-8-4-2-6-14(16)20/h1-8,12,24H,9-11H2,(H,19,21)(H,22,23)/t12-/m0/s1
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PC cid
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Article
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n/an/a 4.70E+3n/an/an/an/an/an/a



Alexandru Ioan Cuza University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human FTase using FPP/dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis

Bioorg Med Chem Lett 25: 4447-52 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.008
BindingDB Entry DOI: 10.7270/Q2XS5ZDS
More data for this
Ligand-Target Pair