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BDBM50499838 CHEMBL3740189

SMILES: O=C(N1CCN(CC1)c1ncccc1C#N)c1cccc(Nc2n[nH]c(=O)c3ccccc23)c1

InChI Key: InChIKey=NOUCHCLPKAGHOK-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50499838   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50499838
PNG
(CHEMBL3740189)
Show SMILES O=C(N1CCN(CC1)c1ncccc1C#N)c1cccc(Nc2n[nH]c(=O)c3ccccc23)c1
Show InChI InChI=1S/C25H21N7O2/c26-16-18-6-4-10-27-23(18)31-11-13-32(14-12-31)25(34)17-5-3-7-19(15-17)28-22-20-8-1-2-9-21(20)24(33)30-29-22/h1-10,15H,11-14H2,(H,28,29)(H,30,33)
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 9.33E+3n/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PARP in human HeLa cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysis

Bioorg Med Chem Lett 25: 5743-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.079
BindingDB Entry DOI: 10.7270/Q2WH2T0J
More data for this
Ligand-Target Pair