BDBM50499952 CHEMBL3741642

SMILES: Cc1cc(cc(C)c1NC(=O)c1cc(nc2ccccc12)-c1ccccc1)C(O)=O

InChI Key: InChIKey=XFVKGKJMJRFZIM-UHFFFAOYSA-N

Data: 1 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50499952   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E2 receptor (Homo sapiens (Human))	BDBM50499952 (CHEMBL3741642) Show SMILES Cc1cc(cc(C)c1NC(=O)c1cc(nc2ccccc12)-c1ccccc1)C(O)=O Show InChI InChI=1S/C25H20N2O3/c1-15-12-18(25(29)30)13-16(2)23(15)27-24(28)20-14-22(17-8-4-3-5-9-17)26-21-11-7-6-10-19(20)21/h3-14H,1-2H3,(H,27,28)(H,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	39	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Antagonist activity at human EP4 receptor				Bioorg Med Chem Lett 26: 105-9 (2016) Article DOI: 10.1016/j.bmcl.2015.11.023 BindingDB Entry DOI: 10.7270/Q2G73HRK
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor (Homo sapiens (Human))	BDBM50499952 (CHEMBL3741642) Show SMILES Cc1cc(cc(C)c1NC(=O)c1cc(nc2ccccc12)-c1ccccc1)C(O)=O Show InChI InChI=1S/C25H20N2O3/c1-15-12-18(25(29)30)13-16(2)23(15)27-24(28)20-14-22(17-8-4-3-5-9-17)26-21-11-7-6-10-19(20)21/h3-14H,1-2H3,(H,27,28)(H,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Antagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation				Bioorg Med Chem Lett 26: 105-9 (2016) Article DOI: 10.1016/j.bmcl.2015.11.023 BindingDB Entry DOI: 10.7270/Q2G73HRK
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor (Homo sapiens (Human))	BDBM50499952 (CHEMBL3741642) Show SMILES Cc1cc(cc(C)c1NC(=O)c1cc(nc2ccccc12)-c1ccccc1)C(O)=O Show InChI InChI=1S/C25H20N2O3/c1-15-12-18(25(29)30)13-16(2)23(15)27-24(28)20-14-22(17-8-4-3-5-9-17)26-21-11-7-6-10-19(20)21/h3-14H,1-2H3,(H,27,28)(H,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.98E+3	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Antagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretrea...				Bioorg Med Chem Lett 26: 105-9 (2016) Article DOI: 10.1016/j.bmcl.2015.11.023 BindingDB Entry DOI: 10.7270/Q2G73HRK
					More data for this Ligand-Target Pair