BDBM50500090 CHEMBL3741473

SMILES: FC(F)(F)c1cccc(Nc2ncnc3ccc(NC(=O)Nc4ccc(CN5CCCCC5)cc4)cc23)c1

InChI Key: InChIKey=RSNNOUWADQQHGE-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50500090   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50500090 (CHEMBL3741473) Show SMILES FC(F)(F)c1cccc(Nc2ncnc3ccc(NC(=O)Nc4ccc(CN5CCCCC5)cc4)cc23)c1 Show InChI InChI=1S/C28H27F3N6O/c29-28(30,31)20-5-4-6-22(15-20)34-26-24-16-23(11-12-25(24)32-18-33-26)36-27(38)35-21-9-7-19(8-10-21)17-37-13-2-1-3-14-37/h4-12,15-16,18H,1-3,13-14,17H2,(H,32,33,34)(H2,35,36,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of wild-type EGFR tyrosine kinase (unknown origin) assessed as ATP level by luminescence analysis				Bioorg Med Chem 24: 179-90 (2016) Article DOI: 10.1016/j.bmc.2015.12.001 BindingDB Entry DOI: 10.7270/Q2SJ1PM0
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50500090 (CHEMBL3741473) Show SMILES FC(F)(F)c1cccc(Nc2ncnc3ccc(NC(=O)Nc4ccc(CN5CCCCC5)cc4)cc23)c1 Show InChI InChI=1S/C28H27F3N6O/c29-28(30,31)20-5-4-6-22(15-20)34-26-24-16-23(11-12-25(24)32-18-33-26)36-27(38)35-21-9-7-19(8-10-21)17-37-13-2-1-3-14-37/h4-12,15-16,18H,1-3,13-14,17H2,(H,32,33,34)(H2,35,36,38)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EGFR tyrosine kinase L858R mutant (unknown origin) assessed as ATP level by luminescence analysis				Bioorg Med Chem 24: 179-90 (2016) Article DOI: 10.1016/j.bmc.2015.12.001 BindingDB Entry DOI: 10.7270/Q2SJ1PM0
					More data for this Ligand-Target Pair