BDBM50500179 CHEMBL3746909

SMILES: C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1ccccc1F

InChI Key: InChIKey=AGZXCSVUZRAJTQ-CABCVRRESA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50500179   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50500179 (CHEMBL3746909) Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1ccccc1F |r| Show InChI InChI=1S/C23H23F2N5O/c1-14-10-15(26)13-30(12-14)21-8-9-27-11-20(21)29-23(31)19-7-6-18(25)22(28-19)16-4-2-3-5-17(16)24/h2-9,11,14-15H,10,12-13,26H2,1H3,(H,29,31)/t14-,15+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of PIM1 kinase (unknown origin) using NH2-AGAGRSRHSSYPAGT-OH as substrate by kinase-Glo assay				J Med Chem 58: 8373-86 (2015) Article DOI: 10.1021/acs.jmedchem.5b01275 BindingDB Entry DOI: 10.7270/Q2H41VGN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM50500179 (CHEMBL3746909) Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1ccccc1F |r| Show InChI InChI=1S/C23H23F2N5O/c1-14-10-15(26)13-30(12-14)21-8-9-27-11-20(21)29-23(31)19-7-6-18(25)22(28-19)16-4-2-3-5-17(16)24/h2-9,11,14-15H,10,12-13,26H2,1H3,(H,29,31)/t14-,15+/m1/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	<3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of PIM3 kinase (unknown origin) using NH2-AGAGRSRHSSYPAGT-OH as substrate by kinase-Glo assay				J Med Chem 58: 8373-86 (2015) Article DOI: 10.1021/acs.jmedchem.5b01275 BindingDB Entry DOI: 10.7270/Q2H41VGN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50500179 (CHEMBL3746909) Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1ccccc1F |r| Show InChI InChI=1S/C23H23F2N5O/c1-14-10-15(26)13-30(12-14)21-8-9-27-11-20(21)29-23(31)19-7-6-18(25)22(28-19)16-4-2-3-5-17(16)24/h2-9,11,14-15H,10,12-13,26H2,1H3,(H,29,31)/t14-,15+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	<3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of PIM2 kinase (unknown origin) using NH2-AGAGRSRHSSYPAGT-OH as substrate by kinase-Glo assay				J Med Chem 58: 8373-86 (2015) Article DOI: 10.1021/acs.jmedchem.5b01275 BindingDB Entry DOI: 10.7270/Q2H41VGN
					More data for this Ligand-Target Pair