null
SMILES: COCC(C)n1cc(C(=O)C(=O)Nc2ccc(OC)nc2)c2ccccc12
InChI Key: InChIKey=JWMPCMACOTWDKX-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tubulin beta chain (Sus scrofa) | BDBM50500399 (CHEMBL3746906) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sheffield Curated by ChEMBL | Assay Description Displacement of [3H]-colchicine from biotinylated porcine tubulin after 2 hrs by competitive binding assay | J Med Chem 58: 9309-33 (2015) Article DOI: 10.1021/acs.jmedchem.5b01312 BindingDB Entry DOI: 10.7270/Q2Z60S2S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tubulin beta chain (Sus scrofa) | BDBM50500399 (CHEMBL3746906) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sheffield Curated by ChEMBL | Assay Description Inhibition of porcine brain tubulin polymerization assessed as reduction in GTP-induced microtubule assembly after 60 mins by OD340 method | J Med Chem 58: 9309-33 (2015) Article DOI: 10.1021/acs.jmedchem.5b01312 BindingDB Entry DOI: 10.7270/Q2Z60S2S | |||||||||||
More data for this Ligand-Target Pair |