Found 7 hits for monomerid = 50500918 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50500918
(CHEMBL3799511)Show SMILES C[C@@H]1CN(CCO1)c1cc(=O)c2cc(cc(CN3CCOc4ccc(F)cc34)c2o1)C(=O)N(C)C |r| Show InChI InChI=1S/C26H28FN3O5/c1-16-14-30(7-8-33-16)24-13-22(31)20-11-17(26(32)28(2)3)10-18(25(20)35-24)15-29-6-9-34-23-5-4-19(27)12-21(23)29/h4-5,10-13,16H,6-9,14-15H2,1-3H3/t16-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Tight binding affinity to human recombinant PI3Kbeta using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 8... |
Bioorg Med Chem Lett 26: 2318-23 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.034 BindingDB Entry DOI: 10.7270/Q2W098ZZ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50500918
(CHEMBL3799511)Show SMILES C[C@@H]1CN(CCO1)c1cc(=O)c2cc(cc(CN3CCOc4ccc(F)cc34)c2o1)C(=O)N(C)C |r| Show InChI InChI=1S/C26H28FN3O5/c1-16-14-30(7-8-33-16)24-13-22(31)20-11-17(26(32)28(2)3)10-18(25(20)35-24)15-29-6-9-34-23-5-4-19(27)12-21(23)29/h4-5,10-13,16H,6-9,14-15H2,1-3H3/t16-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PI3Kalpha using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins by l... |
Bioorg Med Chem Lett 26: 2318-23 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.034 BindingDB Entry DOI: 10.7270/Q2W098ZZ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50500918
(CHEMBL3799511)Show SMILES C[C@@H]1CN(CCO1)c1cc(=O)c2cc(cc(CN3CCOc4ccc(F)cc34)c2o1)C(=O)N(C)C |r| Show InChI InChI=1S/C26H28FN3O5/c1-16-14-30(7-8-33-16)24-13-22(31)20-11-17(26(32)28(2)3)10-18(25(20)35-24)15-29-6-9-34-23-5-4-19(27)12-21(23)29/h4-5,10-13,16H,6-9,14-15H2,1-3H3/t16-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PI3Kgamma using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins by l... |
Bioorg Med Chem Lett 26: 2318-23 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.034 BindingDB Entry DOI: 10.7270/Q2W098ZZ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50500918
(CHEMBL3799511)Show SMILES C[C@@H]1CN(CCO1)c1cc(=O)c2cc(cc(CN3CCOc4ccc(F)cc34)c2o1)C(=O)N(C)C |r| Show InChI InChI=1S/C26H28FN3O5/c1-16-14-30(7-8-33-16)24-13-22(31)20-11-17(26(32)28(2)3)10-18(25(20)35-24)15-29-6-9-34-23-5-4-19(27)12-21(23)29/h4-5,10-13,16H,6-9,14-15H2,1-3H3/t16-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of PI3Kbeta in PTEN deficient human MDA-MB-468 cells assessed as inhibition of AKT phosphorylation at Ser-473 residue after 2 hrs by plate... |
Bioorg Med Chem Lett 26: 2318-23 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.034 BindingDB Entry DOI: 10.7270/Q2W098ZZ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50500918
(CHEMBL3799511)Show SMILES C[C@@H]1CN(CCO1)c1cc(=O)c2cc(cc(CN3CCOc4ccc(F)cc34)c2o1)C(=O)N(C)C |r| Show InChI InChI=1S/C26H28FN3O5/c1-16-14-30(7-8-33-16)24-13-22(31)20-11-17(26(32)28(2)3)10-18(25(20)35-24)15-29-6-9-34-23-5-4-19(27)12-21(23)29/h4-5,10-13,16H,6-9,14-15H2,1-3H3/t16-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Tight binding affinity to human recombinant PI3Kalpha using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after ... |
Bioorg Med Chem Lett 26: 2318-23 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.034 BindingDB Entry DOI: 10.7270/Q2W098ZZ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50500918
(CHEMBL3799511)Show SMILES C[C@@H]1CN(CCO1)c1cc(=O)c2cc(cc(CN3CCOc4ccc(F)cc34)c2o1)C(=O)N(C)C |r| Show InChI InChI=1S/C26H28FN3O5/c1-16-14-30(7-8-33-16)24-13-22(31)20-11-17(26(32)28(2)3)10-18(25(20)35-24)15-29-6-9-34-23-5-4-19(27)12-21(23)29/h4-5,10-13,16H,6-9,14-15H2,1-3H3/t16-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PI3Kdelta using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins by l... |
Bioorg Med Chem Lett 26: 2318-23 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.034 BindingDB Entry DOI: 10.7270/Q2W098ZZ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50500918
(CHEMBL3799511)Show SMILES C[C@@H]1CN(CCO1)c1cc(=O)c2cc(cc(CN3CCOc4ccc(F)cc34)c2o1)C(=O)N(C)C |r| Show InChI InChI=1S/C26H28FN3O5/c1-16-14-30(7-8-33-16)24-13-22(31)20-11-17(26(32)28(2)3)10-18(25(20)35-24)15-29-6-9-34-23-5-4-19(27)12-21(23)29/h4-5,10-13,16H,6-9,14-15H2,1-3H3/t16-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PI3Kbeta using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins by lu... |
Bioorg Med Chem Lett 26: 2318-23 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.034 BindingDB Entry DOI: 10.7270/Q2W098ZZ |
More data for this Ligand-Target Pair | |