null

SMILES: FC(F)(F)c1c(ccn2c(CC3CC3)nnc12)-c1ccc(CNC(=O)c2ccc(cc2)S(F)(=O)=O)cc1

InChI Key: InChIKey=ALLKYFRFVNIHGD-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50503158   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50503158 (CHEMBL4589377) Show SMILES FC(F)(F)c1c(ccn2c(CC3CC3)nnc12)-c1ccc(CNC(=O)c2ccc(cc2)S(F)(=O)=O)cc1 Show InChI InChI=1S/C25H20F4N4O3S/c26-25(27,28)22-20(11-12-33-21(13-15-1-2-15)31-32-23(22)33)17-5-3-16(4-6-17)14-30-24(34)18-7-9-19(10-8-18)37(29,35)36/h3-12,15H,1-2,13-14H2,(H,30,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	4.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Displacement of [3H]JNJ-46281222 from human mGlu2 receptor expressed in CHOK1 cell membranes preincubated for 3 hrs followed by [3H]JNJ-46281222 addi...				J Med Chem 62: 223-233 (2019) Article DOI: 10.1021/acs.jmedchem.8b00051
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50503158 (CHEMBL4589377) Show SMILES FC(F)(F)c1c(ccn2c(CC3CC3)nnc12)-c1ccc(CNC(=O)c2ccc(cc2)S(F)(=O)=O)cc1 Show InChI InChI=1S/C25H20F4N4O3S/c26-25(27,28)22-20(11-12-33-21(13-15-1-2-15)31-32-23(22)33)17-5-3-16(4-6-17)14-30-24(34)18-7-9-19(10-8-18)37(29,35)36/h3-12,15H,1-2,13-14H2,(H,30,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	5.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Displacement of [3H]JNJ-46281222 from human mGlu2 receptor expressed in CHOK1 cell membranes after 1 hr by microbeta scintillation counting method				J Med Chem 62: 223-233 (2019) Article DOI: 10.1021/acs.jmedchem.8b00051
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50503158 (CHEMBL4589377) Show SMILES FC(F)(F)c1c(ccn2c(CC3CC3)nnc12)-c1ccc(CNC(=O)c2ccc(cc2)S(F)(=O)=O)cc1 Show InChI InChI=1S/C25H20F4N4O3S/c26-25(27,28)22-20(11-12-33-21(13-15-1-2-15)31-32-23(22)33)17-5-3-16(4-6-17)14-30-24(34)18-7-9-19(10-8-18)37(29,35)36/h3-12,15H,1-2,13-14H2,(H,30,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHOK1 cell membranes assessed as increase in glutamate-induced [35S]GTPgammaS bin...				J Med Chem 62: 223-233 (2019) Article DOI: 10.1021/acs.jmedchem.8b00051
					More data for this Ligand-Target Pair