BDBM50504180 CHEMBL4559825

SMILES: COc1ccc(cc1Cl)-c1nn(cc1-c1ccncc1)-c1cccc(NC(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1

InChI Key: InChIKey=XFDWYCZIKCNVGE-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50504180   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50504180 (CHEMBL4559825) Show SMILES COc1ccc(cc1Cl)-c1nn(cc1-c1ccncc1)-c1cccc(NC(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1 Show InChI InChI=1S/C30H20ClF6N5O2/c1-44-26-6-5-18(11-25(26)31)27-24(17-7-9-38-10-8-17)16-42(41-27)23-4-2-3-21(15-23)39-28(43)40-22-13-19(29(32,33)34)12-20(14-22)30(35,36)37/h2-16H,1H3,(H2,39,40,43)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	307	n/a	n/a	n/a	n/a	n/a	n/a
University of Sharjah Curated by ChEMBL					Assay Description Inhibition of human p38alpha using MBP as substrate by [gamma-33P]-ATP assay				Eur J Med Chem 183: (2019) Article DOI: 10.1016/j.ejmech.2019.111684
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50504180 (CHEMBL4559825) Show SMILES COc1ccc(cc1Cl)-c1nn(cc1-c1ccncc1)-c1cccc(NC(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1 Show InChI InChI=1S/C30H20ClF6N5O2/c1-44-26-6-5-18(11-25(26)31)27-24(17-7-9-38-10-8-17)16-42(41-27)23-4-2-3-21(15-23)39-28(43)40-22-13-19(29(32,33)34)12-20(14-22)30(35,36)37/h2-16H,1H3,(H2,39,40,43)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.94E+3	n/a	n/a	n/a	n/a
University of Sharjah Curated by ChEMBL					Assay Description Inhibition of recombinant Nanoluc-tagged p38alpha (unknown origin) expressed in HEK293 cells incubated for 2 to 3 mins by NanoBRET assay				Eur J Med Chem 183: (2019) Article DOI: 10.1016/j.ejmech.2019.111684
					More data for this Ligand-Target Pair