BDBM50505091 CHEMBL4075790
SMILES: CCN(CC)CCCNc1cc2nc3\C(CCn3c(=O)c2cc1F)=C\c1ccc(cc1)C(C)C
InChI Key: InChIKey=GZSNGNPLURZQGM-CJLVFECKSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Bloom syndrome protein (Homo sapiens (Human)) | BDBM50505091 (CHEMBL4075790) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 4.90E+3 | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Binding affinity to His-tagged BLM M1111A mutant (unknown origin) expressed in Escherichia coli BL21 (DE3) by ITC assay | J Med Chem 62: 3147-3162 (2019) Article DOI: 10.1021/acs.jmedchem.9b00083 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bloom syndrome protein (Homo sapiens (Human)) | BDBM50505091 (CHEMBL4075790) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Binding affinity to His-tagged BLM (642 to 1296 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) by ITC assay | J Med Chem 62: 3147-3162 (2019) Article DOI: 10.1021/acs.jmedchem.9b00083 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bloom syndrome protein (Homo sapiens (Human)) | BDBM50505091 (CHEMBL4075790) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Binding affinity to His-tagged BLM E1143A mutant (unknown origin) expressed in Escherichia coli BL21 (DE3) by ITC assay | J Med Chem 62: 3147-3162 (2019) Article DOI: 10.1021/acs.jmedchem.9b00083 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bloom syndrome protein (Homo sapiens (Human)) | BDBM50505091 (CHEMBL4075790) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | PubMed | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of His-tagged BLM (642 to 1296 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells assessed as reduction in DNA unwi... | J Med Chem 63: 9752-9772 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bloom syndrome protein (Homo sapiens (Human)) | BDBM50505091 (CHEMBL4075790) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Binding affinity to His-tagged BLM I1168A mutant (unknown origin) expressed in Escherichia coli BL21 (DE3) by ITC assay | J Med Chem 62: 3147-3162 (2019) Article DOI: 10.1021/acs.jmedchem.9b00083 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bloom syndrome protein (Homo sapiens (Human)) | BDBM50505091 (CHEMBL4075790) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 950 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of His-tagged BLM (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in BLM helicase unwinding activity using... | J Med Chem 62: 3147-3162 (2019) Article DOI: 10.1021/acs.jmedchem.9b00083 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bloom syndrome protein (Homo sapiens (Human)) | BDBM50505091 (CHEMBL4075790) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Binding affinity to His-tagged BLM Y995A mutant (unknown origin) expressed in Escherichia coli BL21 (DE3) by ITC assay | J Med Chem 62: 3147-3162 (2019) Article DOI: 10.1021/acs.jmedchem.9b00083 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bloom syndrome protein (Homo sapiens (Human)) | BDBM50505091 (CHEMBL4075790) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.95E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of 5'-biotin labeled duplex forked-DNA binding to BLM (unknown origin) assessed as increase in unbound DNA levels after 1 hr by ELISA | J Med Chem 62: 3147-3162 (2019) Article DOI: 10.1021/acs.jmedchem.9b00083 | |||||||||||
More data for this Ligand-Target Pair |