BDBM50506718 CHEMBL1098827

SMILES: O\N=C1/c2ccccc2-n2c1nc1ccccc1c2=O

InChI Key: InChIKey=PMNWPSRSXHKOQI-GHRIWEEISA-N

Data: 2 IC50  6 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50506718   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
NT-3 growth factor receptor (Homo sapiens (Human))	BDBM50506718 (CHEMBL1098827) Show SMILES O\N=C1/c2ccccc2-n2c1nc1ccccc1c2=O Show InChI InChI=1S/C15H9N3O2/c19-15-9-5-1-3-7-11(9)16-14-13(17-20)10-6-2-4-8-12(10)18(14)15/h1-8,20H/b17-13+	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a
Montana State University Curated by ChEMBL					Assay Description Binding affinity to human partial length TRKC (Q531 to G825 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan method				Eur J Med Chem 161: 179-191 (2019) Article DOI: 10.1016/j.ejmech.2018.10.023
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Homo sapiens (Human))	BDBM50506718 (CHEMBL1098827) Show SMILES O\N=C1/c2ccccc2-n2c1nc1ccccc1c2=O Show InChI InChI=1S/C15H9N3O2/c19-15-9-5-1-3-7-11(9)16-14-13(17-20)10-6-2-4-8-12(10)18(14)15/h1-8,20H/b17-13+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a
Montana State University Curated by ChEMBL					Assay Description Binding affinity to human full-length JNK2 (M1 to Q382 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan method				Eur J Med Chem 161: 179-191 (2019) Article DOI: 10.1016/j.ejmech.2018.10.023
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM50506718 (CHEMBL1098827) Show SMILES O\N=C1/c2ccccc2-n2c1nc1ccccc1c2=O Show InChI InChI=1S/C15H9N3O2/c19-15-9-5-1-3-7-11(9)16-14-13(17-20)10-6-2-4-8-12(10)18(14)15/h1-8,20H/b17-13+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	275	n/a	n/a	n/a	n/a	n/a
Montana State University Curated by ChEMBL					Assay Description Binding affinity to human partial length JNK3 (V28 to Q422 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan method				Eur J Med Chem 161: 179-191 (2019) Article DOI: 10.1016/j.ejmech.2018.10.023
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10/8/9 (Homo sapiens (Human))	BDBM50506718 (CHEMBL1098827) Show SMILES O\N=C1/c2ccccc2-n2c1nc1ccccc1c2=O Show InChI InChI=1S/C15H9N3O2/c19-15-9-5-1-3-7-11(9)16-14-13(17-20)10-6-2-4-8-12(10)18(14)15/h1-8,20H/b17-13+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University Curated by ChEMBL					Assay Description Inhibition of JNK in human MONO-MAC-6 cells assessed as reduction in LPS-induced IL6 production preincubated for 30 mins followed by LPS-stimulation ...				Eur J Med Chem 161: 179-191 (2019) Article DOI: 10.1016/j.ejmech.2018.10.023
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50506718 (CHEMBL1098827) Show SMILES O\N=C1/c2ccccc2-n2c1nc1ccccc1c2=O Show InChI InChI=1S/C15H9N3O2/c19-15-9-5-1-3-7-11(9)16-14-13(17-20)10-6-2-4-8-12(10)18(14)15/h1-8,20H/b17-13+	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a
Montana State University Curated by ChEMBL					Assay Description Binding affinity to human partial length TRKA (G475 to G790 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan method				Eur J Med Chem 161: 179-191 (2019) Article DOI: 10.1016/j.ejmech.2018.10.023
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM50506718 (CHEMBL1098827) Show SMILES O\N=C1/c2ccccc2-n2c1nc1ccccc1c2=O Show InChI InChI=1S/C15H9N3O2/c19-15-9-5-1-3-7-11(9)16-14-13(17-20)10-6-2-4-8-12(10)18(14)15/h1-8,20H/b17-13+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a
Montana State University Curated by ChEMBL					Assay Description Binding affinity to human full-length JNK1 (M1 to Q384 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan method				Eur J Med Chem 161: 179-191 (2019) Article DOI: 10.1016/j.ejmech.2018.10.023
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50506718 (CHEMBL1098827) Show SMILES O\N=C1/c2ccccc2-n2c1nc1ccccc1c2=O Show InChI InChI=1S/C15H9N3O2/c19-15-9-5-1-3-7-11(9)16-14-13(17-20)10-6-2-4-8-12(10)18(14)15/h1-8,20H/b17-13+	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a
Montana State University Curated by ChEMBL					Assay Description Binding affinity to human partial length TRKB (Q547 to G838 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan method				Eur J Med Chem 161: 179-191 (2019) Article DOI: 10.1016/j.ejmech.2018.10.023
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10/8/9 (Homo sapiens (Human))	BDBM50506718 (CHEMBL1098827) Show SMILES O\N=C1/c2ccccc2-n2c1nc1ccccc1c2=O Show InChI InChI=1S/C15H9N3O2/c19-15-9-5-1-3-7-11(9)16-14-13(17-20)10-6-2-4-8-12(10)18(14)15/h1-8,20H/b17-13+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University Curated by ChEMBL					Assay Description Inhibition of JNK in human THP1-Blue cells assessed as reduction in LPS-induced NFkappaB/AP1 activation preincubated for 30 mins followed by LPS-stim...				Eur J Med Chem 161: 179-191 (2019) Article DOI: 10.1016/j.ejmech.2018.10.023
					More data for this Ligand-Target Pair