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SMILES: OC(=O)[C@H]1C2CCC(CC2)[C@@H]1n1cnc2cnc(nc12)-c1c[nH]c2ncc(F)cc12

InChI Key: InChIKey=RSBRJNASPIIEKH-VOGSPBGVSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50507233   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Polymerase basic protein 2


(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)		BDBM50507233
PNG
(CHEMBL4589525)
Show SMILES OC(=O)[C@H]1C2CCC(CC2)[C@@H]1n1cnc2cnc(nc12)-c1c[nH]c2ncc(F)cc12 |r,wU:3.2,wD:10.12,(40.52,-2.61,;41.86,-3.37,;43.19,-2.59,;41.87,-4.91,;43.21,-5.68,;43.22,-7.22,;41.89,-7.99,;40.56,-7.24,;41.32,-5.95,;42.44,-6.85,;40.56,-5.69,;39.25,-4.93,;38.21,-3.8,;36.8,-4.43,;36.98,-5.96,;35.95,-7.12,;36.43,-8.58,;37.93,-8.89,;38.97,-7.74,;38.48,-6.27,;38.42,-10.34,;37.52,-11.59,;38.43,-12.84,;39.89,-12.35,;41.22,-13.12,;42.56,-12.35,;42.55,-10.8,;43.88,-10.03,;41.22,-10.04,;39.88,-10.81,)|
Show InChI InChI=1S/C21H19FN6O2/c22-12-5-13-14(7-24-18(13)23-6-12)19-25-8-15-20(27-19)28(9-26-15)17-11-3-1-10(2-4-11)16(17)21(29)30/h5-11,16-17H,1-4H2,(H,23,24)(H,29,30)/t10?,11?,16-,17-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 190n/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Inhibition of PB2 in Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as reduction in virus induced cell death after 5 days by ...

Eur J Med Chem 162: 249-265 (2019)


Article DOI: 10.1016/j.ejmech.2018.11.015
More data for this
Ligand-Target Pair