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SMILES: OC(=O)[C@H]1C2CCC(CC2)[C@@H]1n1ccc2cnc(nc12)-c1c[nH]c2ncc(F)cc12

InChI Key: InChIKey=QXVOLKZXJNJXRP-DFYNNNJYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50507250   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Polymerase basic protein 2


(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)		BDBM50507250
PNG
(CHEMBL4562249)
Show SMILES OC(=O)[C@H]1C2CCC(CC2)[C@@H]1n1ccc2cnc(nc12)-c1c[nH]c2ncc(F)cc12 |r,wU:3.2,wD:10.12,(18.43,-2.23,;19.77,-2.99,;21.1,-2.21,;19.78,-4.52,;21.12,-5.29,;21.13,-6.83,;19.8,-7.61,;18.47,-6.85,;19.23,-5.56,;20.35,-6.46,;18.47,-5.3,;17.16,-4.55,;16.12,-3.41,;14.71,-4.05,;14.89,-5.58,;13.86,-6.73,;14.34,-8.19,;15.84,-8.5,;16.88,-7.35,;16.4,-5.89,;16.33,-9.96,;15.43,-11.21,;16.34,-12.45,;17.8,-11.97,;19.14,-12.74,;20.47,-11.97,;20.46,-10.42,;21.79,-9.64,;19.13,-9.65,;17.79,-10.43,)|
Show InChI InChI=1S/C22H20FN5O2/c23-14-7-15-16(10-26-19(15)25-9-14)20-24-8-13-5-6-28(21(13)27-20)18-12-3-1-11(2-4-12)17(18)22(29)30/h5-12,17-18H,1-4H2,(H,25,26)(H,29,30)/t11?,12?,17-,18-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 12n/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Inhibition of PB2 in Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as reduction in virus induced cell death after 5 days by ...

Eur J Med Chem 162: 249-265 (2019)


Article DOI: 10.1016/j.ejmech.2018.11.015
BindingDB Entry DOI: 10.7270/Q2PG1W2P
More data for this
Ligand-Target Pair