BDBM50507435 CHEMBL4451879

SMILES: CNC(=O)c1c(oc2cc(N(CCO)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC1(CC1)c1ccccn1)-c1ccc(F)cc1

InChI Key: InChIKey=DSMFZNYMBWVYOE-UHFFFAOYSA-N

Data: 4 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50507435   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatitis C virus NS5B RNA-dependent RNA polymerase (Hepatitis C virus)	BDBM50507435 (CHEMBL4451879) Show SMILES CNC(=O)c1c(oc2cc(N(CCO)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC1(CC1)c1ccccn1)-c1ccc(F)cc1 Show InChI InChI=1S/C34H31FN4O6S/c1-36-33(42)30-26-19-25(22-6-5-7-23(18-22)32(41)38-34(13-14-34)29-8-3-4-15-37-29)27(39(16-17-40)46(2,43)44)20-28(26)45-31(30)21-9-11-24(35)12-10-21/h3-12,15,18-20,40H,13-14,16-17H2,1-2H3,(H,36,42)(H,38,41)	UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	52	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research and Development Curated by ChEMBL					Assay Description Inhibition of HCV genotype 1b NS5B RNA dependent RNA polymerase infected in human HuH7 replicon cells after 3 days by luciferase reporter gene assay				ACS Med Chem Lett 9: 1217-1222 (2018) Article DOI: 10.1021/acsmedchemlett.8b00379
					More data for this Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase (Hepatitis C virus)	BDBM50507435 (CHEMBL4451879) Show SMILES CNC(=O)c1c(oc2cc(N(CCO)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC1(CC1)c1ccccn1)-c1ccc(F)cc1 Show InChI InChI=1S/C34H31FN4O6S/c1-36-33(42)30-26-19-25(22-6-5-7-23(18-22)32(41)38-34(13-14-34)29-8-3-4-15-37-29)27(39(16-17-40)46(2,43)44)20-28(26)45-31(30)21-9-11-24(35)12-10-21/h3-12,15,18-20,40H,13-14,16-17H2,1-2H3,(H,36,42)(H,38,41)	UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	385	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research and Development Curated by ChEMBL					Assay Description Inhibition of HCV genotype 1b NS5B RNA dependent RNA polymerase C316N mutant infected in human HuH7 replicon cells after 3 days by luciferase reporte...				ACS Med Chem Lett 9: 1217-1222 (2018) Article DOI: 10.1021/acsmedchemlett.8b00379
					More data for this Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase (Hepatitis C virus)	BDBM50507435 (CHEMBL4451879) Show SMILES CNC(=O)c1c(oc2cc(N(CCO)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC1(CC1)c1ccccn1)-c1ccc(F)cc1 Show InChI InChI=1S/C34H31FN4O6S/c1-36-33(42)30-26-19-25(22-6-5-7-23(18-22)32(41)38-34(13-14-34)29-8-3-4-15-37-29)27(39(16-17-40)46(2,43)44)20-28(26)45-31(30)21-9-11-24(35)12-10-21/h3-12,15,18-20,40H,13-14,16-17H2,1-2H3,(H,36,42)(H,38,41)	UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	22	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research and Development Curated by ChEMBL					Assay Description Inhibition of HCV genotype 2a JFH1 NS5B RNA dependent RNA polymerase infected in human HuH7 replicon cells after 3 days by luciferase reporter gene a...				ACS Med Chem Lett 9: 1217-1222 (2018) Article DOI: 10.1021/acsmedchemlett.8b00379
					More data for this Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase (Hepatitis C virus)	BDBM50507435 (CHEMBL4451879) Show SMILES CNC(=O)c1c(oc2cc(N(CCO)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC1(CC1)c1ccccn1)-c1ccc(F)cc1 Show InChI InChI=1S/C34H31FN4O6S/c1-36-33(42)30-26-19-25(22-6-5-7-23(18-22)32(41)38-34(13-14-34)29-8-3-4-15-37-29)27(39(16-17-40)46(2,43)44)20-28(26)45-31(30)21-9-11-24(35)12-10-21/h3-12,15,18-20,40H,13-14,16-17H2,1-2H3,(H,36,42)(H,38,41)	UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	35	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research and Development Curated by ChEMBL					Assay Description Inhibition of HCV genotype 1a NS5B RNA dependent RNA polymerase infected in human HuH7 replicon cells after 3 days by luciferase reporter gene assay				ACS Med Chem Lett 9: 1217-1222 (2018) Article DOI: 10.1021/acsmedchemlett.8b00379
					More data for this Ligand-Target Pair