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BDBM50507441 CHEMBL4547789

SMILES: CCN(c1cc2oc(c(C(=O)NC)c2cc1-c1cc(Cl)c(OC)c(c1)C(=O)NC1(CC1)c1ncccn1)-c1ccc(F)cc1)S(C)(=O)=O

InChI Key: InChIKey=KATMITIMPSRCKL-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50507441   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)		BDBM50507441
PNG
(CHEMBL4547789)
Show SMILES CCN(c1cc2oc(c(C(=O)NC)c2cc1-c1cc(Cl)c(OC)c(c1)C(=O)NC1(CC1)c1ncccn1)-c1ccc(F)cc1)S(C)(=O)=O
Show InChI InChI=1S/C34H31ClFN5O6S/c1-5-41(48(4,44)45)26-18-27-23(28(32(43)37-2)29(47-27)19-7-9-21(36)10-8-19)17-22(26)20-15-24(30(46-3)25(35)16-20)31(42)40-34(11-12-34)33-38-13-6-14-39-33/h6-10,13-18H,5,11-12H2,1-4H3,(H,37,43)(H,40,42)
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 6.60n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of HCV genotype 2a JFH1 NS5B RNA dependent RNA polymerase infected in human HuH7 replicon cells after 3 days by luciferase reporter gene a...

ACS Med Chem Lett 9: 1217-1222 (2018)


Article DOI: 10.1021/acsmedchemlett.8b00379
More data for this
Ligand-Target Pair