BDBM50507541 CHEMBL4441465

SMILES: COc1ccc(cn1)-c1ccc(Cn2cc(nn2)-c2cccc(N)c2)cc1

InChI Key: InChIKey=MIIRGIJHJBFFEA-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50507541   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50507541 (CHEMBL4441465) Show SMILES COc1ccc(cn1)-c1ccc(Cn2cc(nn2)-c2cccc(N)c2)cc1 Show InChI InChI=1S/C21H19N5O/c1-27-21-10-9-18(12-23-21)16-7-5-15(6-8-16)13-26-14-20(24-25-26)17-3-2-4-19(22)11-17/h2-12,14H,13,22H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin) after 1 hr by ADP-Glo reagent based luminescent assay				Eur J Med Chem 163: 1-9 (2019) Article DOI: 10.1016/j.ejmech.2018.11.042
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2) (Homo sapiens (Human))	BDBM50507541 (CHEMBL4441465) Show SMILES COc1ccc(cn1)-c1ccc(Cn2cc(nn2)-c2cccc(N)c2)cc1 Show InChI InChI=1S/C21H19N5O/c1-27-21-10-9-18(12-23-21)16-7-5-15(6-8-16)13-26-14-20(24-25-26)17-3-2-4-19(22)11-17/h2-12,14H,13,22H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.730	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of TIE2 (unknown origin) after 4 hrs by ADP-Glo reagent based luminescent assay				Eur J Med Chem 163: 1-9 (2019) Article DOI: 10.1016/j.ejmech.2018.11.042
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50507541 (CHEMBL4441465) Show SMILES COc1ccc(cn1)-c1ccc(Cn2cc(nn2)-c2cccc(N)c2)cc1 Show InChI InChI=1S/C21H19N5O/c1-27-21-10-9-18(12-23-21)16-7-5-15(6-8-16)13-26-14-20(24-25-26)17-3-2-4-19(22)11-17/h2-12,14H,13,22H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EPHB4 (unknown origin) after 4 hrs by ADP-Glo reagent based luminescent assay				Eur J Med Chem 163: 1-9 (2019) Article DOI: 10.1016/j.ejmech.2018.11.042
					More data for this Ligand-Target Pair