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BDBM50507993 CHEMBL4445067

SMILES: Cc1nc(C2CCN(CC2)C(=O)c2ccc(OC(F)(F)F)cc2)c2ccccc2n1

InChI Key: InChIKey=CMLWCJMFHJPJPC-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50507993   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Extracellular signal-regulated kinase 5 (ERK5)


(Homo sapiens (Human))		BDBM50507993
PNG
(CHEMBL4445067)
Show SMILES Cc1nc(C2CCN(CC2)C(=O)c2ccc(OC(F)(F)F)cc2)c2ccccc2n1
Show InChI InChI=1S/C22H20F3N3O2/c1-14-26-19-5-3-2-4-18(19)20(27-14)15-10-12-28(13-11-15)21(29)16-6-8-17(9-7-16)30-22(23,24)25/h2-9,15H,10-13H2,1H3
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Inhibition of His-tagged MAP2K5 activated N-terminal GST-tagged recombinant human ERK5 (1 to 398 residues) expressed in Escherichia coli using biotin...

J Med Chem 62: 928-940 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01606
More data for this
Ligand-Target Pair