BDBM50508393 CHEMBL4464446

SMILES: CN(C1CCN(C1)c1ccc(c(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)C(F)(F)F)C(=O)C=C

InChI Key: InChIKey=JFDLRMQMFZSXEU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50508393   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50508393 (CHEMBL4464446) Show SMILES CN(C1CCN(C1)c1ccc(c(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)C(F)(F)F)C(=O)C=C |t:15| Show InChI InChI=1S/C27H23F3N4O3/c1-3-22(35)33(2)16-10-11-34(14-16)15-8-9-20(27(28,29)30)18(12-15)23-24(26(37)32-25(23)36)19-13-31-21-7-5-4-6-17(19)21/h3-9,12-13,16,31H,1,10-11,14H2,2H3,(H,32,36,37)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Inhibition of human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system in presence of 6 uM ATP by HTRF assa...				J Med Chem 62: 1054-1066 (2019) Article DOI: 10.1021/acs.jmedchem.8b01823
					More data for this Ligand-Target Pair