BDBM50508404 CHEMBL4526325

SMILES: C=CC(=O)N1CCC(CC1)NC1=C(C(=O)NC1=O)c1c[nH]c2ccccc12

InChI Key: InChIKey=ORWGBKLEJAMBBV-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50508404   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50508404 (CHEMBL4526325) Show SMILES C=CC(=O)N1CCC(CC1)NC1=C(C(=O)NC1=O)c1c[nH]c2ccccc12 |t:12| Show InChI InChI=1S/C20H20N4O3/c1-2-16(25)24-9-7-12(8-10-24)22-18-17(19(26)23-20(18)27)14-11-21-15-6-4-3-5-13(14)15/h2-6,11-12,21H,1,7-10H2,(H2,22,23,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.78E+3	n/a	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Inhibition of human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system in presence of 6 uM ATP by HTRF assa...				J Med Chem 62: 1054-1066 (2019) Article DOI: 10.1021/acs.jmedchem.8b01823
					More data for this Ligand-Target Pair