BindingDB PrimarySearch

BDBM50509369 CHEMBL4548361

SMILES: COc1cc(Br)cc2[nH]c(I)c(-c3cnc(o3)-c3ccc[nH]3)c12

InChI Key: InChIKey=NDWPRZFOCQREKV-UHFFFAOYSA-N

Data: 13 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50509369
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Mitogen-activated protein kinase 15 (Homo sapiens (Human))	BDBM50509369 (CHEMBL4548361) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
UiT - The Arctic University of Norway Curated by ChEMBL					Assay Description Inhibition of ERK8 (unknown origin) by [33P]-ATP filter binding kinase assay				J Med Chem 62: 10167-10181 (2019) Article DOI: 10.1021/acs.jmedchem.9b01006
UiT - The Arctic University of Norway Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 (Homo sapiens (Human))	BDBM50509369 (CHEMBL4548361) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
UiT - The Arctic University of Norway Curated by ChEMBL					Assay Description Inhibition of TAK1 (unknown origin) by [33P]-ATP filter binding kinase assay				J Med Chem 62: 10167-10181 (2019) Article DOI: 10.1021/acs.jmedchem.9b01006
UiT - The Arctic University of Norway Curated by ChEMBL					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50509369 (CHEMBL4548361) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
UiT - The Arctic University of Norway Curated by ChEMBL					Assay Description Inhibition of Aurora B (unknown origin) by [33P]-ATP filter binding kinase assay				J Med Chem 62: 10167-10181 (2019) Article DOI: 10.1021/acs.jmedchem.9b01006
UiT - The Arctic University of Norway Curated by ChEMBL					More data for this Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A (Homo sapiens (Human))	BDBM50509369 (CHEMBL4548361) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
UiT - The Arctic University of Norway Curated by ChEMBL					Assay Description Inhibition of DYRK1A (unknown origin) by [33P]-ATP filter binding kinase assay				J Med Chem 62: 10167-10181 (2019) Article DOI: 10.1021/acs.jmedchem.9b01006
UiT - The Arctic University of Norway Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase SIK3 (Homo sapiens)	BDBM50509369 (CHEMBL4548361) Show SMILES Show InChI	MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
UiT - The Arctic University of Norway Curated by ChEMBL					Assay Description Inhibition of SIK3 (unknown origin) by [33P]-ATP filter binding kinase assay				J Med Chem 62: 10167-10181 (2019) Article DOI: 10.1021/acs.jmedchem.9b01006
UiT - The Arctic University of Norway Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 9 (Homo sapiens (Human))	BDBM50509369 (CHEMBL4548361) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
UiT - The Arctic University of Norway Curated by ChEMBL					Assay Description Inhibition of MLK1 (unknown origin) by [33P]-ATP filter binding kinase assay				J Med Chem 62: 10167-10181 (2019) Article DOI: 10.1021/acs.jmedchem.9b01006
UiT - The Arctic University of Norway Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50509369 (CHEMBL4548361) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
UiT - The Arctic University of Norway Curated by ChEMBL					Assay Description Inhibition of PIM1 (unknown origin) by [33P]-ATP filter binding kinase assay				J Med Chem 62: 10167-10181 (2019) Article DOI: 10.1021/acs.jmedchem.9b01006
UiT - The Arctic University of Norway Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase RIPK2 (Homo sapiens (Human))	BDBM50509369 (CHEMBL4548361) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
UiT - The Arctic University of Norway Curated by ChEMBL					Assay Description Inhibition of RIPK2 (unknown origin) by [33P]-ATP filter binding kinase assay				J Med Chem 62: 10167-10181 (2019) Article DOI: 10.1021/acs.jmedchem.9b01006
UiT - The Arctic University of Norway Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50509369 (CHEMBL4548361) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
UiT - The Arctic University of Norway Curated by ChEMBL					Assay Description Inhibition of PIM2 (unknown origin) by [33P]-ATP filter binding kinase assay				J Med Chem 62: 10167-10181 (2019) Article DOI: 10.1021/acs.jmedchem.9b01006
UiT - The Arctic University of Norway Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM50509369 (CHEMBL4548361) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
UiT - The Arctic University of Norway Curated by ChEMBL					Assay Description Inhibition of PIM3 (unknown origin) by [33P]-ATP filter binding kinase assay				J Med Chem 62: 10167-10181 (2019) Article DOI: 10.1021/acs.jmedchem.9b01006
UiT - The Arctic University of Norway Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 2 (Homo sapiens (Human))	BDBM50509369 (CHEMBL4548361) Show SMILES Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
UiT - The Arctic University of Norway Curated by ChEMBL					Assay Description Inhibition of GCK (unknown origin) by [33P]-ATP filter binding kinase assay				J Med Chem 62: 10167-10181 (2019) Article DOI: 10.1021/acs.jmedchem.9b01006
UiT - The Arctic University of Norway Curated by ChEMBL					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50509369 (CHEMBL4548361) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
UiT - The Arctic University of Norway Curated by ChEMBL					Assay Description Inhibition of Aurora A (unknown origin) by [33P]-ATP filter binding kinase assay				J Med Chem 62: 10167-10181 (2019) Article DOI: 10.1021/acs.jmedchem.9b01006
UiT - The Arctic University of Norway Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11 (Homo sapiens (Human))	BDBM50509369 (CHEMBL4548361) Show SMILES Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
UiT - The Arctic University of Norway Curated by ChEMBL					Assay Description Inhibition of MLK3 (unknown origin) by [33P]-ATP filter binding kinase assay				J Med Chem 62: 10167-10181 (2019) Article DOI: 10.1021/acs.jmedchem.9b01006
UiT - The Arctic University of Norway Curated by ChEMBL					More data for this Ligand-Target Pair