BDBM50509977 CHEMBL4463108

SMILES: COc1ccc(Nc2ncc3CSc4ncccc4-c3n2)cc1OC

InChI Key: InChIKey=HGJVACKDUMHHAW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50509977   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50509977 (CHEMBL4463108) Show SMILES COc1ccc(Nc2ncc3CSc4ncccc4-c3n2)cc1OC Show InChI InChI=1S/C18H16N4O2S/c1-23-14-6-5-12(8-15(14)24-2)21-18-20-9-11-10-25-17-13(16(11)22-18)4-3-7-19-17/h3-9H,10H2,1-2H3,(H,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Inhibition of recombinant human KDR incubated for 1 hr using Tyr1 substrate by fluorimetry based Z'-LYTE-Tyr1 Peptide assay				ACS Med Chem Lett 10: 457-462 (2019) Article DOI: 10.1021/acsmedchemlett.8b00499
					More data for this Ligand-Target Pair