BDBM50510162 CHEMBL4567516

SMILES: CC(C)N1CCOc2c1cnn1c(nnc21)-c1ccc2cccc(NCC3CCNCC3)c2n1

InChI Key: InChIKey=ZFJYBIDCQXNLFR-UHFFFAOYSA-N

Data: 3 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50510162   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50510162 (CHEMBL4567516) Show SMILES CC(C)N1CCOc2c1cnn1c(nnc21)-c1ccc2cccc(NCC3CCNCC3)c2n1 Show InChI InChI=1S/C25H30N8O/c1-16(2)32-12-13-34-23-21(32)15-28-33-24(30-31-25(23)33)20-7-6-18-4-3-5-19(22(18)29-20)27-14-17-8-10-26-11-9-17/h3-7,15-17,26-27H,8-14H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Spanish National Cancer Research Centre (CNIO) Curated by ChEMBL					Assay Description Inhibition of His tagged human recombinant PIM1 using PIM tide (ARKRRRHPSGPPTA) as substrate incubated for 1 hr by fluorescence based assay				Eur J Med Chem 168: 87-109 (2019) Article DOI: 10.1016/j.ejmech.2019.02.022
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM50510162 (CHEMBL4567516) Show SMILES CC(C)N1CCOc2c1cnn1c(nnc21)-c1ccc2cccc(NCC3CCNCC3)c2n1 Show InChI InChI=1S/C25H30N8O/c1-16(2)32-12-13-34-23-21(32)15-28-33-24(30-31-25(23)33)20-7-6-18-4-3-5-19(22(18)29-20)27-14-17-8-10-26-11-9-17/h3-7,15-17,26-27H,8-14H2,1-2H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
Spanish National Cancer Research Centre (CNIO) Curated by ChEMBL					Assay Description Inhibition of N-terminal 6-His tagged human recombinant PIM3 using PIM tide (ARKRRRHPSGPPTA) as substrate incubated for 1 hr by fluorescence based as...				Eur J Med Chem 168: 87-109 (2019) Article DOI: 10.1016/j.ejmech.2019.02.022
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50510162 (CHEMBL4567516) Show SMILES CC(C)N1CCOc2c1cnn1c(nnc21)-c1ccc2cccc(NCC3CCNCC3)c2n1 Show InChI InChI=1S/C25H30N8O/c1-16(2)32-12-13-34-23-21(32)15-28-33-24(30-31-25(23)33)20-7-6-18-4-3-5-19(22(18)29-20)27-14-17-8-10-26-11-9-17/h3-7,15-17,26-27H,8-14H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	915	n/a	n/a	n/a	n/a
Spanish National Cancer Research Centre (CNIO) Curated by ChEMBL					Assay Description Inhibition of PIM1 in human NCI-H1299 cells assessed as reduction in BAD phosphorylation at Ser-112 residue incubated for 4 hrs by ELISA				Eur J Med Chem 168: 87-109 (2019) Article DOI: 10.1016/j.ejmech.2019.02.022
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50510162 (CHEMBL4567516) Show SMILES CC(C)N1CCOc2c1cnn1c(nnc21)-c1ccc2cccc(NCC3CCNCC3)c2n1 Show InChI InChI=1S/C25H30N8O/c1-16(2)32-12-13-34-23-21(32)15-28-33-24(30-31-25(23)33)20-7-6-18-4-3-5-19(22(18)29-20)27-14-17-8-10-26-11-9-17/h3-7,15-17,26-27H,8-14H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.65E+3	n/a	n/a	n/a	n/a	n/a	n/a
Spanish National Cancer Research Centre (CNIO) Curated by ChEMBL					Assay Description Inhibition of His tagged human recombinant PIM2 using PIM tide (ARKRRRHPSGPPTA) as substrate incubated for 1 hr by fluorescence based assay				Eur J Med Chem 168: 87-109 (2019) Article DOI: 10.1016/j.ejmech.2019.02.022
					More data for this Ligand-Target Pair