BDBM50510295 CHEMBL4443422
SMILES: Cc1sc(cc1C(=O)N[C@@H](CN)c1ccccc1)-c1ccccc1Cl
InChI Key: InChIKey=GEDDMFGBKRREEU-SFHVURJKSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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DNA Gyrase (Escherichia coli (strain K12)) | BDBM50510295 (CHEMBL4443422) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of Escherichia coli his-tagged DNA gyrase supercoiling activity using pBR322 DNA in presence of ATP incubated for 1 hr by H19 dye based hi... | Bioorg Med Chem Lett 29: 1407-1412 (2019) Article DOI: 10.1016/j.bmcl.2019.03.029 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM50510295 (CHEMBL4443422) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human NaV1.5 expressed in HEK293 cells assessed as decrease in sodium current amplitude at -120 mV holding potential by Qpatch assay | Bioorg Med Chem Lett 29: 1407-1412 (2019) Article DOI: 10.1016/j.bmcl.2019.03.029 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1,3-beta-glucan synthase component GLS2 (Saccharomyces cerevisiae) | BDBM50510295 (CHEMBL4443422) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 6.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human ERG by QPatch assay | Bioorg Med Chem Lett 29: 1407-1412 (2019) Article DOI: 10.1016/j.bmcl.2019.03.029 | |||||||||||
More data for this Ligand-Target Pair |