Found 4 hits for monomerid = 50510509 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50510509
(CHEMBL4532073)Show SMILES CC(C)c1cc(C(C)C)c(c(c1)C(C)C)S(=O)(=O)n1cc2c(n1)c1ccccc1oc2=O Show InChI InChI=1S/C25H28N2O4S/c1-14(2)17-11-19(15(3)4)24(20(12-17)16(5)6)32(29,30)27-13-21-23(26-27)18-9-7-8-10-22(18)31-25(21)28/h7-16H,1-6H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
School of Traditional Chinese Pharmacy
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kalpha (unknown origin) using diC8-PI(4,5)P2 as substrate incubated for 3 hrs by fluorescence polarization assay |
Bioorg Med Chem 27: 2261-2267 (2019)
Article DOI: 10.1016/j.bmc.2019.04.021 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50510509
(CHEMBL4532073)Show SMILES CC(C)c1cc(C(C)C)c(c(c1)C(C)C)S(=O)(=O)n1cc2c(n1)c1ccccc1oc2=O Show InChI InChI=1S/C25H28N2O4S/c1-14(2)17-11-19(15(3)4)24(20(12-17)16(5)6)32(29,30)27-13-21-23(26-27)18-9-7-8-10-22(18)31-25(21)28/h7-16H,1-6H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 990 | n/a | n/a | n/a | n/a | n/a | n/a |
School of Traditional Chinese Pharmacy
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kdelta (unknown origin) using diC8-PI(4,5)P2 as substrate incubated for 3 hrs by fluorescence polarization assay |
Bioorg Med Chem 27: 2261-2267 (2019)
Article DOI: 10.1016/j.bmc.2019.04.021 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50510509
(CHEMBL4532073)Show SMILES CC(C)c1cc(C(C)C)c(c(c1)C(C)C)S(=O)(=O)n1cc2c(n1)c1ccccc1oc2=O Show InChI InChI=1S/C25H28N2O4S/c1-14(2)17-11-19(15(3)4)24(20(12-17)16(5)6)32(29,30)27-13-21-23(26-27)18-9-7-8-10-22(18)31-25(21)28/h7-16H,1-6H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
School of Traditional Chinese Pharmacy
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kgamma (unknown origin) using diC8-PI(4,5)P2 as substrate incubated for 3 hrs by fluorescence polarization assay |
Bioorg Med Chem 27: 2261-2267 (2019)
Article DOI: 10.1016/j.bmc.2019.04.021 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50510509
(CHEMBL4532073)Show SMILES CC(C)c1cc(C(C)C)c(c(c1)C(C)C)S(=O)(=O)n1cc2c(n1)c1ccccc1oc2=O Show InChI InChI=1S/C25H28N2O4S/c1-14(2)17-11-19(15(3)4)24(20(12-17)16(5)6)32(29,30)27-13-21-23(26-27)18-9-7-8-10-22(18)31-25(21)28/h7-16H,1-6H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
School of Traditional Chinese Pharmacy
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kbeta (unknown origin) using diC8-PI(4,5)P2 as substrate incubated for 3 hrs by fluorescence polarization assay |
Bioorg Med Chem 27: 2261-2267 (2019)
Article DOI: 10.1016/j.bmc.2019.04.021 |
More data for this
Ligand-Target Pair | |
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