BDBM50511459 CHEMBL4565569

SMILES: Nc1nc2c(cccc2[nH]1)-c1cccc(Cl)c1Cl

InChI Key: InChIKey=WUFMSEKSVOGWSM-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50511459   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
7,8-dihydro-8-oxoguanine triphosphatase (Homo sapiens (Human))	BDBM50511459 (CHEMBL4565569) Show SMILES Nc1nc2c(cccc2[nH]1)-c1cccc(Cl)c1Cl Show InChI InChI=1S/C13H9Cl2N3/c14-9-5-1-3-7(11(9)15)8-4-2-6-10-12(8)18-13(16)17-10/h1-6H,(H3,16,17,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...				ACS Med Chem Lett 11: 358-364 (2020) Article DOI: 10.1021/acsmedchemlett.9b00420
					More data for this Ligand-Target Pair