BDBM50513366 CHEMBL4435185

SMILES: Cc1ccc(C)c2c1CCC21CCN(CCc2cnn(c2)-c2nccc3c2nc[nH]c3=O)CC1

InChI Key: InChIKey=YAWHCFISAFZXHF-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50513366   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 4B (Homo sapiens (Human))	BDBM50513366 (CHEMBL4435185) Show SMILES Cc1ccc(C)c2c1CCC21CCN(CCc2cnn(c2)-c2nccc3c2nc[nH]c3=O)CC1 Show InChI InChI=1S/C27H30N6O/c1-18-3-4-19(2)23-21(18)5-8-27(23)9-13-32(14-10-27)12-7-20-15-31-33(16-20)25-24-22(6-11-28-25)26(34)30-17-29-24/h3-4,6,11,15-17H,5,7-10,12-14H2,1-2H3,(H,29,30,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of N-terminal GST-tagged recombinant human KDM4B (1 to 500 residues) expressed in baculovirus infected Sf9 insect cells assessed as decrea...				Eur J Med Chem 177: 316-337 (2019) Article DOI: 10.1016/j.ejmech.2019.05.041
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5C (Homo sapiens (Human))	BDBM50513366 (CHEMBL4435185) Show SMILES Cc1ccc(C)c2c1CCC21CCN(CCc2cnn(c2)-c2nccc3c2nc[nH]c3=O)CC1 Show InChI InChI=1S/C27H30N6O/c1-18-3-4-19(2)23-21(18)5-8-27(23)9-13-32(14-10-27)12-7-20-15-31-33(16-20)25-24-22(6-11-28-25)26(34)30-17-29-24/h3-4,6,11,15-17H,5,7-10,12-14H2,1-2H3,(H,29,30,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	214	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of KDM5C (unknown origin) assessed as decrease in demethylation of substrate using peptide (H3(1-21)K4-Me3-GGKBiotin) as substrate and 2OG...				Eur J Med Chem 177: 316-337 (2019) Article DOI: 10.1016/j.ejmech.2019.05.041
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM50513366 (CHEMBL4435185) Show SMILES Cc1ccc(C)c2c1CCC21CCN(CCc2cnn(c2)-c2nccc3c2nc[nH]c3=O)CC1 Show InChI InChI=1S/C27H30N6O/c1-18-3-4-19(2)23-21(18)5-8-27(23)9-13-32(14-10-27)12-7-20-15-31-33(16-20)25-24-22(6-11-28-25)26(34)30-17-29-24/h3-4,6,11,15-17H,5,7-10,12-14H2,1-2H3,(H,29,30,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	114	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of KDM5B (unknown origin) assessed as decrease in demethylation of substrate using peptide (H3(1-21)K4-Me3-GGKBiotin) as substrate and 2OG...				Eur J Med Chem 177: 316-337 (2019) Article DOI: 10.1016/j.ejmech.2019.05.041
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4A (Homo sapiens (Human))	BDBM50513366 (CHEMBL4435185) Show SMILES Cc1ccc(C)c2c1CCC21CCN(CCc2cnn(c2)-c2nccc3c2nc[nH]c3=O)CC1 Show InChI InChI=1S/C27H30N6O/c1-18-3-4-19(2)23-21(18)5-8-27(23)9-13-32(14-10-27)12-7-20-15-31-33(16-20)25-24-22(6-11-28-25)26(34)30-17-29-24/h3-4,6,11,15-17H,5,7-10,12-14H2,1-2H3,(H,29,30,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	143	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of N-terminal His-tagged recombinant human KDM4A (1 to 359 residues) expressed in Escherichia coli assessed as decrease in demethylation o...				Eur J Med Chem 177: 316-337 (2019) Article DOI: 10.1016/j.ejmech.2019.05.041
					More data for this Ligand-Target Pair