BDBM50514365 CHEMBL4587036

SMILES: CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C=O

InChI Key: InChIKey=LDBSUIDAABZHKW-OQNPQIFMSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50514365   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
20S proteasome (Homo sapiens (Human))	BDBM50514365 (CHEMBL4587036) Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C=O |r| Show InChI InChI=1S/C90H162N38O20/c1-49(2)40-54(48-129)117-83(147)66(42-51(5)6)128-84(148)65(41-50(3)4)119-71(135)46-113-69(133)44-112-70(134)45-114-73(137)56(20-12-34-106-85(94)95)120-78(142)60(22-14-36-108-87(98)99)124-80(144)62(24-16-38-110-89(102)103)126-82(146)64(30-31-68(93)132)127-81(145)63(25-17-39-111-90(104)105)125-79(143)61(23-15-37-109-88(100)101)123-77(141)59(19-9-11-33-92)122-76(140)58(18-8-10-32-91)121-75(139)57(21-13-35-107-86(96)97)118-72(136)47-115-74(138)67(116-52(7)130)43-53-26-28-55(131)29-27-53/h26-29,48-51,54,56-67,131H,8-25,30-47,91-92H2,1-7H3,(H2,93,132)(H,112,134)(H,113,133)(H,114,137)(H,115,138)(H,116,130)(H,117,147)(H,118,136)(H,119,135)(H,120,142)(H,121,139)(H,122,140)(H,123,141)(H,124,144)(H,125,143)(H,126,146)(H,127,145)(H,128,148)(H4,94,95,106)(H4,96,97,107)(H4,98,99,108)(H4,100,101,109)(H4,102,103,110)(H4,104,105,111)/t54-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of human 20S proteasome using Suc-LLVY-AMC as substrate measured every 5 mins for 120 mins by fluorescence based assay				J Med Chem 63: 334-348 (2020) Article DOI: 10.1021/acs.jmedchem.9b01694
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