null

SMILES: CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(cc2O1)N1CCN(CC(N)=O)CC1

InChI Key: InChIKey=TVWUXEGJFJCUJM-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50514949   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM50514949 (CHEMBL4483551 | US10988478, Example 187) Show SMILES CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(cc2O1)N1CCN(CC(N)=O)CC1 Show InChI InChI=1S/C23H27N7O3/c1-23(2)12-15-10-17(27-22(32)16-13-26-30-5-3-4-25-21(16)30)18(11-19(15)33-23)29-8-6-28(7-9-29)14-20(24)31/h3-5,10-11,13H,6-9,12,14H2,1-2H3,(H2,24,31)(H,27,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description Kinase activities were assayed using the Transcreener-Fluorecescence polarization platform (BelBrook Labs, Madison, Wis., USA) that measures amounts ...				US Patent US10988478 (2021)
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM50514949 (CHEMBL4483551 | US10988478, Example 187) Show SMILES CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(cc2O1)N1CCN(CC(N)=O)CC1 Show InChI InChI=1S/C23H27N7O3/c1-23(2)12-15-10-17(27-22(32)16-13-26-30-5-3-4-25-21(16)30)18(11-19(15)33-23)29-8-6-28(7-9-29)14-20(24)31/h3-5,10-11,13H,6-9,12,14H2,1-2H3,(H2,24,31)(H,27,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human recombinant full length His6-tagged IRAK4 expressed in baculovirus expression system using H-KKARFSRFAGSSPSQSSMVAR as substrate i...				J Med Chem 62: 6223-6240 (2019) Article DOI: 10.1021/acs.jmedchem.9b00439
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM50514949 (CHEMBL4483551 | US10988478, Example 187) Show SMILES CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(cc2O1)N1CCN(CC(N)=O)CC1 Show InChI InChI=1S/C23H27N7O3/c1-23(2)12-15-10-17(27-22(32)16-13-26-30-5-3-4-25-21(16)30)18(11-19(15)33-23)29-8-6-28(7-9-29)14-20(24)31/h3-5,10-11,13H,6-9,12,14H2,1-2H3,(H2,24,31)(H,27,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of IRAK4 in human THP1-Xblue-MD2-CD14 cells assessed as reduction in LPS-induced NFkappaB transcription by measuring alkaline phosphatase ...				J Med Chem 62: 6223-6240 (2019) Article DOI: 10.1021/acs.jmedchem.9b00439
					More data for this Ligand-Target Pair