BDBM50515636 CHEMBL4459244

SMILES: CC(C)(C)NC(=O)C(N(Cc1ccc(OCc2ccccc2F)cc1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O

InChI Key: InChIKey=XTIBFYHFGPXURQ-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50515636   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MDM2-MDMX (Homo sapiens (Human))	BDBM50515636 (CHEMBL4459244) Show SMILES CC(C)(C)NC(=O)C(N(Cc1ccc(OCc2ccccc2F)cc1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O Show InChI InChI=1S/C30H29ClFN3O5/c1-30(2,3)34-28(37)27(25-22-13-10-20(31)14-24(22)33-26(25)29(38)39)35(17-36)15-18-8-11-21(12-9-18)40-16-19-6-4-5-7-23(19)32/h4-14,17,27,33H,15-16H2,1-3H3,(H,34,37)(H,38,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	740	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant N-terminal domain of MDM2 (1 to 118 residues) expressed in Escherichia coli BL21 (DE3) cell...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588
					More data for this Ligand-Target Pair
MDM2-MDMX (Homo sapiens (Human))	BDBM50515636 (CHEMBL4459244) Show SMILES CC(C)(C)NC(=O)C(N(Cc1ccc(OCc2ccccc2F)cc1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O Show InChI InChI=1S/C30H29ClFN3O5/c1-30(2,3)34-28(37)27(25-22-13-10-20(31)14-24(22)33-26(25)29(38)39)35(17-36)15-18-8-11-21(12-9-18)40-16-19-6-4-5-7-23(19)32/h4-14,17,27,33H,15-16H2,1-3H3,(H,34,37)(H,38,39)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	8.64E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588
					More data for this Ligand-Target Pair