BDBM50515771 CHEMBL4528047
SMILES: Cc1nnc2CC[C@@H](Nc3ccc(Cl)cc3)c3cc(ccc3-n12)-c1cnn(C)c1
InChI Key: InChIKey=MDRXOFSNECSECW-HXUWFJFHSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Bromodomain and extra-terminal motif (BET) (Homo sapiens (Human)) | BDBM50515771 (CHEMBL4528047) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Chinese Academy of Sciences Curated by ChEMBL | Assay Description Binding affinity to human recombinant BRD2 BD2 (349 to 460 residues) by fluorescence polarization assay | Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111633 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain and extra-terminal motif (BET) (Homo sapiens (Human)) | BDBM50515771 (CHEMBL4528047) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Chinese Academy of Sciences Curated by ChEMBL | Assay Description Binding affinity to human recombinant BRD3 BD2 (306 to 417 residues) by fluorescence polarization assay | Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111633 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 (Homo sapiens (Human)) | BDBM50515771 (CHEMBL4528047) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Chinese Academy of Sciences Curated by ChEMBL | Assay Description Binding affinity to human recombinant BRD4 BD2 (333 to 460 residues) by fluorescence polarization assay | Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111633 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain and extra-terminal motif (BET) (Homo sapiens (Human)) | BDBM50515771 (CHEMBL4528047) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | 78 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Chinese Academy of Sciences Curated by ChEMBL | Assay Description Binding affinity to human recombinant BRD3 BD1 (24 to 144 residues) by fluorescence polarization assay | Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111633 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 (Homo sapiens (Human)) | BDBM50515771 (CHEMBL4528047) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Chinese Academy of Sciences Curated by ChEMBL | Assay Description Binding affinity to human recombinant BRD4 BD1 (44 to 168 residues) by fluorescence polarization assay | Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111633 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain and extra-terminal motif (BET) (Homo sapiens (Human)) | BDBM50515771 (CHEMBL4528047) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | 96 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Chinese Academy of Sciences Curated by ChEMBL | Assay Description Binding affinity to human recombinant BRD2 BD1 (72 to 205 residues) by fluorescence polarization assay | Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111633 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain and extra-terminal motif (BET) (Homo sapiens (Human)) | BDBM50515771 (CHEMBL4528047) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a |
University of Chinese Academy of Sciences Curated by ChEMBL | Assay Description Binding affinity to human partial length BRD2 BD2 isoform 1 (E348 to D455 residues) expressed in bacterial expression system by bromoscan assay | Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111633 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain and extra-terminal motif (BET) (Homo sapiens (Human)) | BDBM50515771 (CHEMBL4528047) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a |
University of Chinese Academy of Sciences Curated by ChEMBL | Assay Description Binding affinity to human partial length BRDT bromodomain 1 isoform b (N21 to E137 residues) expressed in bacterial expression system by bromoscan as... | Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111633 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain and extra-terminal motif (BET) (Homo sapiens (Human)) | BDBM50515771 (CHEMBL4528047) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a |
University of Chinese Academy of Sciences Curated by ChEMBL | Assay Description Binding affinity to human partial length BRDT bromodomain 2 isoform b (K250 to E382 residues) expressed in bacterial expression system by bromoscan a... | Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111633 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain and extra-terminal motif (BET) (Homo sapiens (Human)) | BDBM50515771 (CHEMBL4528047) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a |
University of Chinese Academy of Sciences Curated by ChEMBL | Assay Description Binding affinity to human partial length BRD3 BD2 (G306 to P416 residues) expressed in bacterial expression system by bromoscan assay | Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111633 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain and extra-terminal motif (BET) (Homo sapiens (Human)) | BDBM50515771 (CHEMBL4528047) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a |
University of Chinese Academy of Sciences Curated by ChEMBL | Assay Description Binding affinity to human partial length BRD3 BD1 (P24 to E144 residues) expressed in bacterial expression system by bromoscan assay | Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111633 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 (Homo sapiens (Human)) | BDBM50515771 (CHEMBL4528047) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a |
University of Chinese Academy of Sciences Curated by ChEMBL | Assay Description Binding affinity to human partial length BRD4 BD1 isoform long (N44 to E168 residues) expressed in bacterial expression system by bromoscan assay | Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111633 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 (Homo sapiens (Human)) | BDBM50515771 (CHEMBL4528047) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a |
University of Chinese Academy of Sciences Curated by ChEMBL | Assay Description Binding affinity to human partial length BRD4 BD2 isoform long (K333 to E460 residues) expressed in bacterial expression system by bromoscan assay | Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111633 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain and extra-terminal motif (BET) (Homo sapiens (Human)) | BDBM50515771 (CHEMBL4528047) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a |
University of Chinese Academy of Sciences Curated by ChEMBL | Assay Description Binding affinity to human partial length BRD2 BD1 isoform 1 (K71 to N194 residues) expressed in bacterial expression system by bromoscan assay | Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111633 | |||||||||||
More data for this Ligand-Target Pair |