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SMILES: COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(\N=N\c4ccc(OC)cc4)c3F)cc12

InChI Key: InChIKey=OUUBNLFYTCOBBQ-CYYJNZCTSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50516607   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase B-raf


(Homo sapiens (Human))		BDBM50516607
PNG
(CHEMBL4530882)
Show SMILES COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(\N=N\c4ccc(OC)cc4)c3F)cc12
Show InChI InChI=1S/C21H16F2N6O3/c1-31-13-5-3-11(4-6-13)26-27-16-8-7-15(22)17(18(16)23)20(30)25-12-9-14-19(24-10-12)28-29-21(14)32-2/h3-10H,1-2H3,(H,25,30)(H,24,28,29)/b27-26+
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PC cid
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Article
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n/an/a 92n/an/an/an/an/an/a



University Medical Center Groningen

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal GST/His6-tagged BRAF V600E mutant (Q417 to H766 residues) expressed in Sf9 insect cells using MEK1 as subs...

Eur J Med Chem 179: 133-146 (2019)


Article DOI: 10.1016/j.ejmech.2019.06.042
More data for this
Ligand-Target Pair