BindingDB logo
myBDB logout

BDBM50517775 CHEMBL4540070

SMILES: COc1cccc(\C=C\C(=O)c2ccc(NC(=O)c3cc4cc5cc(C)ccc5nc4s3)cc2)c1

InChI Key: InChIKey=OROYVJGETKQDEB-NTUHNPAUSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50517775   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50517775
PNG
(CHEMBL4540070)
Show SMILES COc1cccc(\C=C\C(=O)c2ccc(NC(=O)c3cc4cc5cc(C)ccc5nc4s3)cc2)c1
Show InChI InChI=1S/C29H22N2O3S/c1-18-6-12-25-21(14-18)16-22-17-27(35-29(22)31-25)28(33)30-23-10-8-20(9-11-23)26(32)13-7-19-4-3-5-24(15-19)34-2/h3-17H,1-2H3,(H,30,33)/b13-7+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.90E+3n/an/an/an/an/an/a



Al-Azhar University

Curated by ChEMBL


Assay Description
Inhibition of His6-tagged EGFR cytoplasmic domain (645 to 1186 residues) (unknown origin) expressed in baculovirus infected Sf9 insect cells after 10...

Bioorg Med Chem 27: 1076-1086 (2019)


Article DOI: 10.1016/j.bmc.2019.02.012
More data for this
Ligand-Target Pair