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SMILES: COc1cc2nc(Nc3cccc(c3)S(N)(=O)=O)nc(NCc3ccco3)c2cc1OC

InChI Key: InChIKey=YHAKMGZJWXDLCS-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50518220   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Rattus norvegicus)		BDBM50518220
PNG
(CHEMBL4540726)
Show SMILES COc1cc2nc(Nc3cccc(c3)S(N)(=O)=O)nc(NCc3ccco3)c2cc1OC
Show InChI InChI=1S/C21H21N5O5S/c1-29-18-10-16-17(11-19(18)30-2)25-21(26-20(16)23-12-14-6-4-8-31-14)24-13-5-3-7-15(9-13)32(22,27)28/h3-11H,12H2,1-2H3,(H2,22,27,28)(H2,23,24,25,26)
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n/an/a 284n/an/an/an/an/an/a



Kasetsart University

Curated by ChEMBL


Assay Description
Inhibition of rat lung PDE5 using [3H]cGMP as substrate measured after 10 mins by scintillation counting method

Bioorg Med Chem Lett 29: 267-270 (2019)


Article DOI: 10.1016/j.bmcl.2018.11.043
More data for this
Ligand-Target Pair