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SMILES: C(Nc1nc(Nc2ccc(cc2)N2CCOCC2)nc2ccccc12)c1cccs1

InChI Key: InChIKey=WZHUSGVNWCEPTJ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50518226   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Rattus norvegicus)		BDBM50518226
PNG
(CHEMBL4534674)
Show SMILES C(Nc1nc(Nc2ccc(cc2)N2CCOCC2)nc2ccccc12)c1cccs1
Show InChI InChI=1S/C23H23N5OS/c1-2-6-21-20(5-1)22(24-16-19-4-3-15-30-19)27-23(26-21)25-17-7-9-18(10-8-17)28-11-13-29-14-12-28/h1-10,15H,11-14,16H2,(H2,24,25,26,27)
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n/an/a 514n/an/an/an/an/an/a



Kasetsart University

Curated by ChEMBL


Assay Description
Inhibition of rat lung PDE5 using [3H]cGMP as substrate measured after 10 mins by scintillation counting method

Bioorg Med Chem Lett 29: 267-270 (2019)


Article DOI: 10.1016/j.bmcl.2018.11.043
More data for this
Ligand-Target Pair