BindingDB PrimarySearch

null

SMILES: NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3CCCO3)n([C@H]3CCCNC3)c2n1

InChI Key: InChIKey=ITQFRPBHRRDOKY-PXYINDEMSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50518505
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50518505 (CHEMBL4518492) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi Curated by ChEMBL					Assay Description Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assay				Bioorg Med Chem Lett 29: 491-495 (2019) Article DOI: 10.1016/j.bmcl.2018.12.015
Sanofi Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50518505 (CHEMBL4518492) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi Curated by ChEMBL					Assay Description Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assay				Bioorg Med Chem Lett 29: 491-495 (2019) Article DOI: 10.1016/j.bmcl.2018.12.015
Sanofi Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50518505 (CHEMBL4518492) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi Curated by ChEMBL					Assay Description Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assay				Bioorg Med Chem Lett 29: 491-495 (2019) Article DOI: 10.1016/j.bmcl.2018.12.015
Sanofi Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50518505 (CHEMBL4518492) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi Curated by ChEMBL					Assay Description Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assay				Bioorg Med Chem Lett 29: 491-495 (2019) Article DOI: 10.1016/j.bmcl.2018.12.015
Sanofi Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50518505 (CHEMBL4518492) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.40	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi Curated by ChEMBL					Assay Description Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assay				Bioorg Med Chem Lett 29: 491-495 (2019) Article DOI: 10.1016/j.bmcl.2018.12.015
Sanofi Curated by ChEMBL					More data for this Ligand-Target Pair
1,3-beta-glucan synthase component GSC2 (Saccharomyces cerevisiae)	BDBM50518505 (CHEMBL4518492) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi Curated by ChEMBL					Assay Description Inhibition of human ERG				Bioorg Med Chem Lett 29: 491-495 (2019) Article DOI: 10.1016/j.bmcl.2018.12.015
Sanofi Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1/pim-2/pim-3 (Homo sapiens (Human))	BDBM50518505 (CHEMBL4518492) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	69	n/a	n/a	n/a	n/a
Sanofi Curated by ChEMBL					Assay Description Inhibition of PIM in human KG1 cells assessed as reduction in pS6 level				Bioorg Med Chem Lett 29: 491-495 (2019) Article DOI: 10.1016/j.bmcl.2018.12.015
Sanofi Curated by ChEMBL					More data for this Ligand-Target Pair
1,3-beta-glucan synthase component GSC2 (Saccharomyces cerevisiae)	BDBM50518505 (CHEMBL4518492) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi Curated by ChEMBL					Assay Description Inhibition of human ERG				Bioorg Med Chem Lett 29: 491-495 (2019) Article DOI: 10.1016/j.bmcl.2018.12.015
Sanofi Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1/pim-2/pim-3 (Homo sapiens (Human))	BDBM50518505 (CHEMBL4518492) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	137	n/a	n/a	n/a	n/a
Sanofi Curated by ChEMBL					Assay Description Inhibition of PIM in human KG1 cells assessed as reduction in pS6 level				Bioorg Med Chem Lett 29: 491-495 (2019) Article DOI: 10.1016/j.bmcl.2018.12.015
Sanofi Curated by ChEMBL					More data for this Ligand-Target Pair