BDBM50519422 CHEMBL4549272

SMILES: CC(C)(O)C(=O)Nc1cc(Oc2ccc(Nc3nccc4[nH]cc(-c5ccc(F)cc5)c(=O)c34)cc2F)ccn1

InChI Key: InChIKey=ZINUEVNIMBKMMA-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50519422   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50519422 (CHEMBL4549272) Show SMILES CC(C)(O)C(=O)Nc1cc(Oc2ccc(Nc3nccc4[nH]cc(-c5ccc(F)cc5)c(=O)c34)cc2F)ccn1 Show InChI InChI=1S/C29H23F2N5O4/c1-29(2,39)28(38)36-24-14-19(9-11-32-24)40-23-8-7-18(13-21(23)31)35-27-25-22(10-12-33-27)34-15-20(26(25)37)16-3-5-17(30)6-4-16/h3-15,39H,1-2H3,(H,33,35)(H,34,37)(H,32,36,38)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Central China Normal University Curated by ChEMBL					Assay Description Inhibition of purified recombinant MET kinase domain (unknown origin) using biotin as substrate preincubated for 5 mins followed by substrate additio...				Eur J Med Chem 185: (2020) Article DOI: 10.1016/j.ejmech.2019.111803
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50519422 (CHEMBL4549272) Show SMILES CC(C)(O)C(=O)Nc1cc(Oc2ccc(Nc3nccc4[nH]cc(-c5ccc(F)cc5)c(=O)c34)cc2F)ccn1 Show InChI InChI=1S/C29H23F2N5O4/c1-29(2,39)28(38)36-24-14-19(9-11-32-24)40-23-8-7-18(13-21(23)31)35-27-25-22(10-12-33-27)34-15-20(26(25)37)16-3-5-17(30)6-4-16/h3-15,39H,1-2H3,(H,33,35)(H,34,37)(H,32,36,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Central China Normal University Curated by ChEMBL					Assay Description Inhibition of purified recombinant VEGFR2 kinase domain (unknown origin) using biotin as substrate preincubated for 5 mins followed by substrate addi...				Eur J Med Chem 185: (2020) Article DOI: 10.1016/j.ejmech.2019.111803
					More data for this Ligand-Target Pair