BDBM50519428 CHEMBL4578452

SMILES: CCn1cc(-c2ccc(F)cc2)c(=O)c2c(Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)c(F)c3)nccc12

InChI Key: InChIKey=QHFDSDLYUFSYMZ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50519428   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50519428 (CHEMBL4578452) Show SMILES CCn1cc(-c2ccc(F)cc2)c(=O)c2c(Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)c(F)c3)nccc12 Show InChI InChI=1S/C31H25F2N5O3/c1-2-38-17-23(18-5-7-20(32)8-6-18)29(39)28-25(38)12-14-35-30(28)36-21-9-10-26(24(33)15-21)41-22-11-13-34-27(16-22)37-31(40)19-3-4-19/h5-17,19H,2-4H2,1H3,(H,35,36)(H,34,37,40)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.38E+3	n/a	n/a	n/a	n/a	n/a	n/a
Central China Normal University Curated by ChEMBL					Assay Description Inhibition of purified recombinant VEGFR2 kinase domain (unknown origin) using biotin as substrate preincubated for 5 mins followed by substrate addi...				Eur J Med Chem 185: (2020) Article DOI: 10.1016/j.ejmech.2019.111803
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50519428 (CHEMBL4578452) Show SMILES CCn1cc(-c2ccc(F)cc2)c(=O)c2c(Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)c(F)c3)nccc12 Show InChI InChI=1S/C31H25F2N5O3/c1-2-38-17-23(18-5-7-20(32)8-6-18)29(39)28-25(38)12-14-35-30(28)36-21-9-10-26(24(33)15-21)41-22-11-13-34-27(16-22)37-31(40)19-3-4-19/h5-17,19H,2-4H2,1H3,(H,35,36)(H,34,37,40)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Central China Normal University Curated by ChEMBL					Assay Description Inhibition of purified recombinant MET kinase domain (unknown origin) using biotin as substrate preincubated for 5 mins followed by substrate additio...				Eur J Med Chem 185: (2020) Article DOI: 10.1016/j.ejmech.2019.111803
					More data for this Ligand-Target Pair