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BDBM50520125 CHEMBL4578661

SMILES: Cc1cc(F)ccc1-c1cc(Cn2ccn(C)c2=N)cc(c1)C(=O)NCc1cccc(Cl)c1

InChI Key: InChIKey=TVZUKBJFTYWVNB-UHFFFAOYSA-N

Data: 1 Kd

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50520125   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))		BDBM50520125
PNG
(CHEMBL4578661)
Show SMILES Cc1cc(F)ccc1-c1cc(Cn2ccn(C)c2=N)cc(c1)C(=O)NCc1cccc(Cl)c1
Show InChI InChI=1S/C26H24ClFN4O/c1-17-10-23(28)6-7-24(17)20-11-19(16-32-9-8-31(2)26(32)29)12-21(14-20)25(33)30-15-18-4-3-5-22(27)13-18/h3-14,29H,15-16H2,1-2H3,(H,30,33)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 0.140n/an/an/an/an/a



Frederick National Laboratory for Cancer Research

Curated by ChEMBL


Assay Description
Competitive inhibition of human N-terminal His6-SUMO tagged WDR5 (22 to 334 residues) expressed in Escherichia coli BL21-Gold(DE3) cells using 10-mer...

J Med Chem 63: 656-675 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01608
More data for this
Ligand-Target Pair