BDBM50520336 CHEMBL4470042
SMILES: Cc1cc(C)n2nc(CCc3cc(O)n4nc5ccccc5c4n3)nc2n1
InChI Key: InChIKey=XLDHVTAGYSWHEX-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM50520336 (CHEMBL4470042) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Frontier Medicines Curated by ChEMBL | Assay Description Inhibition of human PDE10A2 using cAMP substrate by HTRF assay | J Med Chem 63: 4430-4444 (2020) Article DOI: 10.1021/acs.jmedchem.9b01581 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM50520336 (CHEMBL4470042) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. Curated by ChEMBL | Assay Description Inhibition of human PDE10A using cAMP as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by HTRF detecti... | Bioorg Med Chem 27: 3692-3706 (2019) Article DOI: 10.1016/j.bmc.2019.07.010 | |||||||||||
More data for this Ligand-Target Pair |