BDBM50521288 CHEMBL4438770

SMILES: CCOC(=O)Nc1cc(ccc1NC(=O)OC(C)(C)C)N(CC#C)Cc1ccc(F)cc1

InChI Key: InChIKey=PHUNLNCZCLKHCM-UHFFFAOYSA-N

Data: 3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50521288   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
KCNQ (Kv7) potassium channel (Homo sapiens (Human))	BDBM50521288 (CHEMBL4438770) Show SMILES CCOC(=O)Nc1cc(ccc1NC(=O)OC(C)(C)C)N(CC#C)Cc1ccc(F)cc1 Show InChI InChI=1S/C24H28FN3O4/c1-6-14-28(16-17-8-10-18(25)11-9-17)19-12-13-20(26-23(30)32-24(3,4)5)21(15-19)27-22(29)31-7-2/h1,8-13,15H,7,14,16H2,2-5H3,(H,26,30)(H,27,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.42E+3	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Agonist activity at human KCNQ4 expressed in CHOK1 cells by whole cell patch clamp assay				ACS Med Chem Lett 10: 27-33 (2019) Article DOI: 10.1021/acsmedchemlett.8b00315
					More data for this Ligand-Target Pair
KCNQ (Kv7) potassium channel (Homo sapiens (Human))	BDBM50521288 (CHEMBL4438770) Show SMILES CCOC(=O)Nc1cc(ccc1NC(=O)OC(C)(C)C)N(CC#C)Cc1ccc(F)cc1 Show InChI InChI=1S/C24H28FN3O4/c1-6-14-28(16-17-8-10-18(25)11-9-17)19-12-13-20(26-23(30)32-24(3,4)5)21(15-19)27-22(29)31-7-2/h1,8-13,15H,7,14,16H2,2-5H3,(H,26,30)(H,27,29)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.37E+3	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Agonist activity at human KCNQ5 expressed in CHOK1 cells by whole cell patch clamp assay				ACS Med Chem Lett 10: 27-33 (2019) Article DOI: 10.1021/acsmedchemlett.8b00315
					More data for this Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2 (Rattus norvegicus)	BDBM50521288 (CHEMBL4438770) Show SMILES CCOC(=O)Nc1cc(ccc1NC(=O)OC(C)(C)C)N(CC#C)Cc1ccc(F)cc1 Show InChI InChI=1S/C24H28FN3O4/c1-6-14-28(16-17-8-10-18(25)11-9-17)19-12-13-20(26-23(30)32-24(3,4)5)21(15-19)27-22(29)31-7-2/h1,8-13,15H,7,14,16H2,2-5H3,(H,26,30)(H,27,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Agonist activity at rat KCNQ2 expressed in CHOK1 cells by whole cell patch clamp assay				ACS Med Chem Lett 10: 27-33 (2019) Article DOI: 10.1021/acsmedchemlett.8b00315
					More data for this Ligand-Target Pair