BDBM50521484 CHEMBL4553847

SMILES: CCOCCn1cc(-c2ccc(NC(=O)Nc3cc(on3)C(C)(C)C)cc2)c2c(N)ncnc12

InChI Key: InChIKey=DPKIZOKNKFLJEC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50521484   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50521484 (CHEMBL4553847) Show SMILES CCOCCn1cc(-c2ccc(NC(=O)Nc3cc(on3)C(C)(C)C)cc2)c2c(N)ncnc12 Show InChI InChI=1S/C24H29N7O3/c1-5-33-11-10-31-13-17(20-21(25)26-14-27-22(20)31)15-6-8-16(9-7-15)28-23(32)29-19-12-18(34-30-19)24(2,3)4/h6-9,12-14H,5,10-11H2,1-4H3,(H2,25,26,27)(H2,28,29,30,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of recombinant human FLT3 (564 to end residues) using EAIYAAPFAKKK as substrate measured after 40 mins in presence of [gamma-33P]-ATP by s...				J Med Chem 62: 4158-4173 (2019) Article DOI: 10.1021/acs.jmedchem.9b00223
					More data for this Ligand-Target Pair