BDBM50521492 CHEMBL4439044

SMILES: CCOCCn1cc(-c2ccc(NC(=O)Nc3cc(on3)C(C)(C)C)c(F)c2)c2c(N)ncnc12

InChI Key: InChIKey=LWPWQCCHKZARBH-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50521492   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50521492 (CHEMBL4439044) Show SMILES CCOCCn1cc(-c2ccc(NC(=O)Nc3cc(on3)C(C)(C)C)c(F)c2)c2c(N)ncnc12 Show InChI InChI=1S/C24H28FN7O3/c1-5-34-9-8-32-12-15(20-21(26)27-13-28-22(20)32)14-6-7-17(16(25)10-14)29-23(33)30-19-11-18(35-31-19)24(2,3)4/h6-7,10-13H,5,8-9H2,1-4H3,(H2,26,27,28)(H2,29,30,31,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of recombinant human FLT3 (564 to end residues) using EAIYAAPFAKKK as substrate measured after 40 mins in presence of [gamma-33P]-ATP by s...				J Med Chem 62: 4158-4173 (2019) Article DOI: 10.1021/acs.jmedchem.9b00223
					More data for this Ligand-Target Pair