BDBM50521629 CHEMBL4458373

SMILES: CCN1CCN(CC1)c1cc(Nc2nc(C)c(s2)-c2ccc(NC(=O)Nc3cc(CC)on3)cc2)ncn1

InChI Key: InChIKey=QHKSJWQHGLAARI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50521629   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50521629 (CHEMBL4458373) Show SMILES CCN1CCN(CC1)c1cc(Nc2nc(C)c(s2)-c2ccc(NC(=O)Nc3cc(CC)on3)cc2)ncn1 Show InChI InChI=1S/C26H31N9O2S/c1-4-20-14-22(33-37-20)31-25(36)30-19-8-6-18(7-9-19)24-17(3)29-26(38-24)32-21-15-23(28-16-27-21)35-12-10-34(5-2)11-13-35/h6-9,14-16H,4-5,10-13H2,1-3H3,(H,27,28,29,32)(H2,30,31,33,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	122	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal 6x-His-tagged c-KIT (547 to 935 residues)/(694 to 753 residues deletion) expressed in baculovirus infected...				J Med Chem 62: 3940-3957 (2019) Article DOI: 10.1021/acs.jmedchem.8b01845
					More data for this Ligand-Target Pair