null

SMILES: Cl.Cl.Cc1c(cnn1-c1ccc(F)cc1)C(=O)Nc1nc(C2CCC2)c(CCN2CCCCC2)s1

InChI Key: InChIKey=AMCRGAFJVJDYAS-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50521996   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 4 (Rattus norvegicus)	BDBM50521996 (CHEMBL4459940) Show SMILES Cl.Cl.Cc1c(cnn1-c1ccc(F)cc1)C(=O)Nc1nc(C2CCC2)c(CCN2CCCCC2)s1 Show InChI InChI=1S/C25H30FN5OS/c1-17-21(16-27-31(17)20-10-8-19(26)9-11-20)24(32)29-25-28-23(18-6-5-7-18)22(33-25)12-15-30-13-3-2-4-14-30/h8-11,16,18H,2-7,12-15H2,1H3,(H,28,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Inhibition of rat TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye based				Bioorg Med Chem 27: 3775-3787 (2019) Article DOI: 10.1016/j.bmc.2019.05.041
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (Homo sapiens (Human))	BDBM50521996 (CHEMBL4459940) Show SMILES Cl.Cl.Cc1c(cnn1-c1ccc(F)cc1)C(=O)Nc1nc(C2CCC2)c(CCN2CCCCC2)s1 Show InChI InChI=1S/C25H30FN5OS/c1-17-21(16-27-31(17)20-10-8-19(26)9-11-20)24(32)29-25-28-23(18-6-5-7-18)22(33-25)12-15-30-13-3-2-4-14-30/h8-11,16,18H,2-7,12-15H2,1H3,(H,28,29,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.850	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Inhibition of human TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye based				Bioorg Med Chem 27: 3775-3787 (2019) Article DOI: 10.1016/j.bmc.2019.05.041
					More data for this Ligand-Target Pair